Biosensor regeneration via substrate electric potential: A physical mechanism

Rui-Bin Jiang; Lei, U.
June 2010
Applied Physics Letters;6/28/2010, Vol. 96 Issue 26, p263701
Academic Journal
Literatures showed that the immune type biosensors can be regenerated by applying a voltage (Δ[uppercase_phi_synonym]) across the combined macromolecules but the underlying physics was not clarified. By incorporating an electric double layer force and a van der Waals force into a weight-ensemble Brownian dynamics simulation, we found that the dissociation rate constant for biotin-streptavidin increases exponentially with Δ[uppercase_phi_synonym], and reaches 418-fold when Δ[uppercase_phi_synonym] equals 1 V. Macroscopic diffusion simulations using such enhanced dissociation rate constants agree with the previous experiments, and explain quantitatively the finding that the regeneration using square-wave voltage is superior to that using saw-tooth voltage.


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