Separation of Pharmaceutical Enantiomers using Supercritical Fluid Technology

Sekhon, Bhupinder Singh
April 2010
International Journal of PharmTech Research;Apr2010, Vol. 2 Issue 2, p1695
Academic Journal
The use of supercritical fluids as chromatographic mobile phases provides rapid separations with high efficiency, favoring their use in enantioselective separations. Supercritical fluid technology (SFC) is a versatile tool in the purification, enantioseparation and large-scale production of enantiomers of pharmaceuticals over comparable liquid chromatographic methods and is gaining popularity in pharmaceutical industry. The addition of organic modifiers and additives to the supercritical carbon dioxide mobile phase extends the utility of packed column SFC to polar and even ionic compounds. SFC/MS is employed for detection of impurity and confirmation / identification of enantiomers.


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