Simultaneous Estimation of Nimesulide and Paracetamol in Solid Dosage Form by Rp-Hplc Method

Gharge, Deepali; Dhaba, Pandurang
April 2010
International Journal of PharmTech Research;Apr2010, Vol. 2 Issue 2, p1330
Academic Journal
A simple, specific, accurate and precise reverse phase high pressure liquid chromatographic method has been developed for the simultaneous determination of nimesulide and paracetamol from tablets by reverse phase C18 column (HiQsil C18, 250 mm x 4.6 mm). The sample was analyzed using Methanol: Ammonium acetate buffer in the ratio of 80:20, (pH adjusted to 7.0 with triethylamine) as a mobile phase at a flow rate of 1.0 ml/min and detection at 276.0 nm. The retention time for paracetamol and nimesulide was found to be 3.00 and 4.245 min respectively, and recoveries from tablet were between 95 and 105 %. The method can be used for estimation of combination of these drugs in tablets.


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