TITLE

FIRST AND SECOND DERIVATIVE SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF OLANZAPINE IN PHARMACEUTICAL FORMULATION

AUTHOR(S)
Patel, Vivek M.; Patel, Jigar A.; Havele, Shweta S.; Dhaneshwar, Sunil R.
PUB. DATE
January 2010
SOURCE
International Journal of ChemTech Research;Jan2010, Vol. 2 Issue 1, p756
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Simple, fast and reliable derivative spectrophotometric methods were developed for determination of olanzapine in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in methanol. The quantitative determination of the drug was carried out using the first derivative values measured at 222 nm and the second derivative values measured at 230 nm (n=6). Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of olanzapine using 2-10 μg/ml for first and second derivative spectrophotometric method. The calibration graphs constructed at their wavelength of determination were found to be linear for UV and derivative spectrophotometric methods. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. Developed spectrophotometric methods in this study are simple, accurate, precise, specific, sensitive, reproducible and can be directly and easily applied to pharmaceutical dosage form.
ACCESSION #
51973519

 

Related Articles

  • SECOND ORDER DERIVATIVE SPECTROPHOTOMETRIC ESTIMATION OF VENLAFAXINE HYDROCHLORIDE IN BULK AND PHARMACEUTICAL FORMULATIONS. Shirvi, Vimal D.; Kumar, G. Vijaya; Channabasavaraj, K. P. // International Journal of ChemTech Research;Jan2010, Vol. 2 Issue 1, p572 

    A simple, precise and economical second order derivative method has been developed for the estimation of Venlafaxine hydrochloride in bulk and pharmaceutical formulations. In this method Venlafaxine hydrochloride showed two sharp peak at 244 and 298 nm when n=1 and linearity was measured at 298...

  • SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ATORVASTATIN CALCIUM AND AMLODIPINE BESYLATE IN TABLET DOSAGE FORMS. CHAUDHARI, BHARAT G.; PATEL, ASHOK B. // International Journal of ChemTech Research;Jan2010, Vol. 2 Issue 1, p633 

    A simple and economical dual wavelength spectrophotometric method has been developed for the simultaneous estimation of atorvastatin calcium and amlodipine besylate in their combined dosage forms. The method was based on property of additivity of absorbances. The two wavelengths on amlodipine...

  • Fast Dissolving Oral Films: An Innovative Drug Delivery System and Dosage Form. Arya, Arun; Chandra, Amrish; Sharma, Vijay; Pathak, Kamla // International Journal of ChemTech Research;Jan2010, Vol. 2 Issue 1, p576 

    Fast-dissolving drug-delivery systems were first developed in the late 1970s as an alternative to tablets, capsules, and syrups for pediatric and geriatric patients who experience difficulties swallowing traditional oral soliddosage forms. In response to this need, a variety of orally...

  • UV-VIS SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF GABAPENTIN AND METHYLCOBALAMIN IN BULK AND TABLET. Galande, Varsha R.; Baheti, K. G.; Dehghan, M. H. // International Journal of ChemTech Research;Jan2010, Vol. 2 Issue 1, p695 

    Fixed dose combination tablet containing Gabapentin & Methylcobalamin is widely used for peripheral neuropathy. A simple, economic & precise UV-Vis spectrophotometric method has been developed for the estimation of Gabapentin & Methylcobalamin in tablet dosage form. The estimation was based upon...

  • Formulation, Development and Evaluation of fast disintegrating tablets of Rizatriptan benzoate using novel adjuvants. Chaudhary, Sunita A.; Mehta, Tejal A.; Chaudhary, Ankit B. // International Journal of ChemTech Research;Apr2010, Vol. 2 Issue 2, p1026 

    RZT is potent anti migraine drug having agonist activity at the 5-hydroxytryptamine (5-HT) 1B and 5-HT 1D receptor. It commonly used for relief of headaches in treatment of migraine. Conventional tablets of RZT are not capable of rapid action, which is required for immediate relief from migraine...

  • Preformulation studies for Amoxicillin trihydrate and Dicloxacillin sodium as Mouth Dissolve tablets. Swamivelmanickam, M.; Valliappan, K.; Gangi Reddy, P.; Madhukar, A.; Manavalan, R. // International Journal of ChemTech Research;Oct2009, Vol. 1 Issue 4, p1032 

    Preformulation is the first step in the rational development of dosage form of a drug substance and it is defined as an investigation of physical chemical properties of a drug substance alone and when combined with excipients. Differential scanning calorimetry was used to examine the thermal...

  • SIMULTANEOUS DETERMINATION OF ATORVASTATIN CALCIUM AND TELMISARTAN IN TABLET DOSAGE FORM BY SPECTROPHOTOMETRY. Patil, U. P.; Gandhi, S. V.; Sengar, M. R.; Rajmane, V. S. // International Journal of ChemTech Research;Oct2009, Vol. 1 Issue 4, p970 

    Three accurate, precise, sensitive and economical procedures for simultaneous estimation of Atorvastatin Calcium and Telmisartan in tablet dosage form have been developed. The methods employed were absorbance correction method (I), first order derivative spectroscopic method (II) and duel...

  • UV-Spectrophotometric methods for estimation of Valsartan in bulk and tablet dosage form. Gupta, K. R.; Wadodkar, A. R.; Wadodkar, S. G. // International Journal of ChemTech Research;Apr2010, Vol. 2 Issue 2, p985 

    Two simple, precise and accurate UV spectrophotometric methods has been developed and validated for the estimation of valsartan (VAL) in bulk and tablet dosage form. The zero order spectra of valsartan in methanol shows ?max at 250.0 nm and estimation was carried out by A(1% 1cm) and by...

  • Advances in Pharmaceutical Coatings. Pawar, Avinash S.; Bageshwar, Deepak V.; Khanvilkar, Vineeta V.; Khanvilkar, Vilasrao J. // International Journal of ChemTech Research;Jan2010, Vol. 2 Issue 1, p733 

    Recent trends in pharmaceutical technologies are towards the development of coating methods which overcomes the various disadvantages associated with solvent based coatings. In these newer technologies coating materials are directly coated onto solid dosage forms without using any solvent and...

Share

Read the Article

Courtesy of AIRBUS FRANCE S.A.S.

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics