TITLE

UV-VIS SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF GABAPENTIN AND METHYLCOBALAMIN IN BULK AND TABLET

AUTHOR(S)
Galande, Varsha R.; Baheti, K. G.; Dehghan, M. H.
PUB. DATE
January 2010
SOURCE
International Journal of ChemTech Research;Jan2010, Vol. 2 Issue 1, p695
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Fixed dose combination tablet containing Gabapentin & Methylcobalamin is widely used for peripheral neuropathy. A simple, economic & precise UV-Vis spectrophotometric method has been developed for the estimation of Gabapentin & Methylcobalamin in tablet dosage form. The estimation was based upon measurement of absorbance of tablet in distilled water at λmax 351nm for Methylcobalamin and 405nm for Gabapentin after reacting with 0.2% ninhydrine in N, N'- dimethylformamide. Beer Lambert's law obeyed over a concentration range of 50-300 μg/ml for Gabapentin (r² = 0.9949) & 1-7 μg/ml for Methylcobalamin (r² = 0.9993). The mean results of estimation in tablet were 100.43±0.15% & 100.48±0.18% by standard curve method and 100.58±0.17% and 102.31±1.25% by double point standardization of the label claim for Gabapentin & Methylcobalamin respectively. The method has been validated with respect to linearity, range, accuracy & precision.
ACCESSION #
51973511

Tags: TECHNICAL chemistry;  CHEMICAL reactions;  ULTRAVIOLET spectrometry;  SPECTROPHOTOMETRY;  DOSAGE of drugs;  ADMINISTRATION of drugs;  DRUG development;  TABLETS (Medicine)

 

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