TITLE

SIMULTANEOUS UV-SPECTROPHOTOMETRIC DETERMINATION OF AMLODIPINE BESYLATE AND NEBIVOLOL HYDROCHLORIDE IN TABLET DOSAGE FORM

AUTHOR(S)
CHANDNANI, V. C.; GUPTA, K. R.; CHOPDE, C. T.; KUNJWANI, H. K.; MANIKRAO, A. M.; SHIVHARE, S. C.
PUB. DATE
January 2010
SOURCE
International Journal of ChemTech Research;Jan2010, Vol. 2 Issue 1, p69
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Two simple spectrophotometric methods have been developed for simultaneous determination of Amlodipine besylate and Nebivolol hydrochloride in tablet formulation. The first method is Absorbance correction method based on determination of Amlodipine besylate at 365 nm using its absorptivity value and Nebivolol hydrochloride at 280 nm after deduction of absorbance due to Amlodipine besylate. The second method is based on Absorbance ratio in which wavelengths selected were 269 nm, an isoabsorptive point and 280 nm as λmax of Nebivolol hydrochloride. The methods were validated in terms of accuracy, precision, ruggedness and specificity. The methods can be routinely adopted for quality control of these drugs in tablet.
ACCESSION #
51973420

Tags: SPECTROPHOTOMETRY;  AMLODIPINE;  TABLETS (Medicine);  DOSAGE forms of drugs;  NEBIVOLOL hydrochloride;  ABSORBANCE scale (Spectroscopy);  WAVELENGTHS;  HYDROCHLORIC acid;  OPACITY (Optics)

 

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