TITLE

Synthesis, characterisation and pharmacological evaluation of novel 4-aryl 3-chloro n-pyridine 2-yl 2- azetidinone

AUTHOR(S)
Ramalakshmishmi, Natarajan; Deepa, Selvaraj; Antro, Jenny; Arunkumar, Subramani; Puratchikody, Ayarivan; Bharathi, Raj Vijaya
PUB. DATE
October 2009
SOURCE
International Journal of ChemTech Research;Oct2009, Vol. 1 Issue 4, p1000
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In the present study 3-chloro 4-Aryl N-Pyridine -2-yl 2-Azetidinone derivatives were prepared based on the literature review. All the synthesized compounds showed characteristic I.R, ¹H-NMR, Peaks and expected molecular ion peak (M+) in the spectral studies. All the compounds were subjected to leptospirocidal study. Among the synthesized compounds C1 ,C2 ,C3 ,C4 ,C5 and C12 showed significant activity. And the compounds C8 ,C9 ,C10 ,C11 showed moderate activity. From the above summary it reveals that forming Azetidinone nucleus at the side chain of 2- amino pyridine showed significant leptospirocidal activity.
ACCESSION #
51973338

 

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