TITLE

DEVELOPMENT AND VALIDATION OF SIMULTANEOUS UV-SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF LEVOFLOXACIN AND AMBROXOL IN TABLETS

AUTHOR(S)
Avhad, Makarand; Bonde, C. G.
PUB. DATE
October 2009
SOURCE
International Journal of ChemTech Research;Oct2009, Vol. 1 Issue 4, p873
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
An accurate, specific and precise UV spectrophotometric method was developed for the simultaneous determination of levofloxacin (LVF) and ambroxol (AMB) in pharmaceutical dosage forms. The method involves formation of Q-absorbance equation at 219 (isoabsorptive point) and at 287 nm, using distilled water as a solvent. The linearity for both levofloxacin and ambroxol was in the range of 2-14 μg/ml and 5-35 μg/ml respectively. The % recovery was found to be 100- 101% and 101-102% for levofloxacin and ambroxol respectively indicating proposed method is accurate and precise for simultaneous estimation of levofloxacin and ambroxol in tablets.
ACCESSION #
51973320

 

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