Novel composites materials from functionalized polymers and silver coated titanium oxide capable for calcium phosphate induction, control of orthopedic biofilm infections: an “in vitro” study

Tyllianakis, M.; Dalas, E.; Christofidou, M.; Kallitsis, J. K.; Chrissanthopoulos, A.; Koutsoukos, P. G.; Bartzavali, C.; Gourdoupi, N.; Papadimitriou, K.; Oikonomou, E. K.; Yannopoulos, S. N.; Sevastos, D.
July 2010
Journal of Materials Science: Materials in Medicine;Jul2010, Vol. 21 Issue 7, p2201
Academic Journal
Three copolymers containing the functional groups P=O, S=O and C=O were prepared, and upon the introduction in calcium phosphate aqueous solutions at physiological conditions, “in vitro” were induced the precipitation of calcium phosphate crystals. The investigation of the crystal growth process was done at constant supersaturation. It is suggested that the negative end of the above functional groups acts as the active site for nucleation of the inorganic phase. In order to obtain the copolymer further antimicrobial activity, titania (TiO2) nanocrystals were incorporated in the polymer matrix after silver coverage by UV radiation. The antimicrobial resistance of the composite material (copolymer-titania/Ag) was tested against Staphylococcus epidermidis (SEM), Staphylococcus aureus (SAM), Candida parapsilosis (CAM) and Pseudomonas aeruginosa (PAM), microorganisms, using cut parts of “π-plate” that covered with the above mentioned composite. The antimicrobial effect increased as the size of the nanocrystals TiO2/Ag decreased, the maximum achieved with the third polymer that contained also quartenary ammonium groups.


Related Articles

  • The Double Nucleation Model for Sickle Cell Haemoglobin Polymerization: Full Integration and Comparison with Experimental Data. Terkia Medkour; Frank Ferrone; Frédéric Galactéros; Patrick Hannaert // Acta Biotheoretica;Jun2008, Vol. 56 Issue 1/2, p103 

    Abstract  Sickle cell haemoglobin (HbS) polymerization reduces erythrocyte deformability, causing deleterous vaso-occlusions. The double-nucleation model states that polymers grow from HbS aggregates, the nuclei, (i) in solution (homogeneous nucleation), (ii) onto existing polymers...

  • The Authors Reply:. Sage, Andrew P.; Tintut, Yin; Demer, Linda L. // Kidney International;Apr2011, Vol. 79 Issue 8, p921 

    A response by Andrew P. Sage, Yin Tintut, and Linda L. Demer to a letter to the editor about their article regarding the formation of calcium phosphate nanocrystal independently of cells under hyperphosphatemic conditions in vitro is presented.

  • Bioactive glass induced in vitro apatite formation on composite GBR membranes. Tirri, Teemu; Rich, Jaana; Wolke, Joop; Seppälä, Jukka; Yli-Urpo, Antti; Närhi, Timo O. // Journal of Materials Science: Materials in Medicine;Aug2008, Vol. 19 Issue 8, p2919 

    The aim of this study was to investigate in vitro bioactivity of different thermoplastic biodegradable barrier membranes. Three experimental GBR membranes were fabricated using Poly(ε-caprolactone-co- d, l-lactide) P(CL/DL-LA) and particulate bioactive glass S53P4 (BAG; granule size...

  • Negative capacitance in polymer-nanocrystal composites. Bakueva, L.; Konstantatos, G.; Musikhin, S.; Ruda, H.E.; Shik, A. // Applied Physics Letters;10/18/2004, Vol. 85 Issue 16, p3567 

    The effect of negative capacitance (NC) was observed and investigated in conducting polymers with embedded PbS nanocrystals. NC occurred for signal frequencies up to 1 MHz and was absent in control samples without nanocrystals. The amplitude of NC increased with the applied bias and was...

  • Adherence of Pseudomonas aeruginosa to inanimate polymers including biomaterials. Stone, J H; Gabriel, M M; Ahearn, D G // Journal of Industrial Microbiology & Biotechnology;Jul99, Vol. 23 Issue 1, p713 

    Cells of Pseudomonas aeruginosa were adhered to polymethyl methacrylate, polyvinyl acetate, polyvinyl chloride, polyhydroxyethyl methacrylate, mixed-acrylic, silicone, and natural latex materials. Planktonic bacteria and bacteria that adhered to the test materials were compared for their uptake...

  • TIMESCALES IN BUBBLE NUCLEATION EVENTS FOR THE FORMATION OF MICROCELLULAR BIODEGRADABLE FOAMS. Iannace, Salvatore; Di Maio, Ernesto // AIP Conference Proceedings;9/1/2008, Vol. 1042 Issue 1, p3 

    In this work, the nucleating ability of different micro and nano sized nucleating agents for the foaming of thermoplastic biodegradable semi-crystalline polymer will be reviewed. In particular, the efficiency of the nucleating agent in inducing the formation of the gaseous phase will be compared...

  • Effect of ethyl-α-hydroxymethylacrylate on selected properties of copolymers and ACP resin composites. Antonucci, Joseph; Fowler, Bruce; Weir, Michael; Skrtic, Drago; Stansbury, Jeffrey // Journal of Materials Science: Materials in Medicine;Oct2008, Vol. 19 Issue 10, p3263 

    There is an increased interest in the development of bioactive polymeric dental composites and related materials that have potential for mineralized tissue regeneration and preservation. This study explores how the substitution of ethyl α-hydroxymethylacryate (EHMA) for 2-hydroxyethyl...

  • Inactivation of microbes and macromolecules by atmospheric-pressure plasma jets. Lackmann, Jan-Wilm; Bandow, Julia // Applied Microbiology & Biotechnology;Jul2014, Vol. 98 Issue 14, p6205 

    Plasma is ionized gas, which is found in various forms in nature and can also be generated artificially. A variety of cold atmospheric-pressure plasmas are currently being investigated for their clinical utility, and first studies reporting on the treatment of patients showed that plasma...

  • An in vitro study of composites of poly(L-lactide-co-ε-caprolactone), β-tricalcium phosphate and ciprofloxacin intended for local treatment of osteomyelitis. Ahola, Niina; Männistö, Noora; Veiranto, Minna; Karp, Matti; Rich, Jaana; Efimov, Alexander; Seppälä, Jukka; Kellomäki, Minna // Biomatter;Apr-Jun2013, Vol. 3 Issue 2, p1 

    Osteomyelitis is a bacterial disease that can become chronic, and treatment often includes a surgical operation to remove infected bone. The aim of this study was to develop and investigate in vitro bone filling composite materials that release ciprofloxacin to kill any remaining bacteria and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics