TITLE

Fiber scaffolds of polysialic acid via electrospinning for peripheral nerve regeneration

AUTHOR(S)
Assmann, Ulrike; Szentivanyi, Andreas; Stark, Yvonne; Scheper, Thomas; Berski, Silke; Dräger, Gerald; Schuster, Robert H.
PUB. DATE
July 2010
SOURCE
Journal of Materials Science: Materials in Medicine;Jul2010, Vol. 21 Issue 7, p2115
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Fiber scaffolds of bioactive polysialic acid have been prepared via electrospinning for peripheral nerve regeneration. The diameter, morphology and alignment of fibers in scaffolds were adjusted by variation of electrospinning parameters, which are decisive for the cell-scaffold interaction. Due to the high water solubility of polysialic acid (poly-α-2,8- N-acetylneuraminic acid) a photoactive derivative (poly-α-2,8- N-pentenoylneuraminic acid) was used to obtain stable fiber scaffolds in water by photochemical crosslinking. At the optimized fiber scaffolds good cell viability and directed cell proliferation along the fibers was achieved by cell tests with immortalized Schwann cells.
ACCESSION #
51931015

 

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