TITLE

A nanoencapsulated hypocrellin A prepared by an improved microemulsion method for photodynamic treatment

AUTHOR(S)
Lin Zhou; Yu-Wei Ning; Shao-Hua Wei; Yu-Ying Feng; Jia-Hong Zhou; Bo-Yang Yu; Jian Shen
PUB. DATE
July 2010
SOURCE
Journal of Materials Science: Materials in Medicine;Jul2010, Vol. 21 Issue 7, p2095
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A new hypocrellin A (HA) encapsulated silica nanoparticles was prepared by an improved microemulsion method based on the unique character of cetyl trimethyl ammonium bromide (CTAB). Stable aqueous dispersions of the HA-loaded nanoparticles, with the diameter about 50 nm, owned superior photo-stability and singlet oxygen generation ability to free HA. In vitro studies demonstrated the active uptake of HA-doped nanoparticles into the cytosol of HeLa (human cervix epithelioid carcinoma) cells. Significant morphology change and phototoxicity to such impregnated tumor cells was observed upon irradiation with light. Thus, the potential of using this method to prepare silica nanoparticles as drug carriers for photodynamic therapy has been demonstrated.
ACCESSION #
51931008

 

Related Articles

  • Positively charged calcium phosphate/polymer nanoparticles for photodynamic therapy. Klesing, J.; Wiehe, A.; Gitter, B.; Gräfe, S.; Epple, M. // Journal of Materials Science: Materials in Medicine;Mar2010, Vol. 21 Issue 3, p887 

    The charge of nanoparticles influences their ability to pass through the cellular membrane, and a positive charge should be beneficial. The negative charge of calcium phosphate nanoparticles with an inner shell of carboxymethyl cellulose (CMC) was reversed by adding an outer shell of...

  • Spray drying formulation of hollow spherical aggregates of silica nanoparticles by experimental design. Cheow, Wean Sin; Li, Selina; Hadinoto, Kunn // Chemical Engineering Research & Design: Transactions of the Inst;May/Jun2010, Vol. 88 Issue 5/6, p673 

    The present work employs an experimental design methodology to optimize the spray-drying production of micron-size hollow aggregates of biocompatible silica nanoparticles that are aimed to serve as drug delivery vehicles in inhaled photodynamic therapy. To effectively deliver the nanoparticles...

  • Controlled cellular uptake and drug efficacy of nanotherapeutics. Sungsook Ahn; Eunseok Seo; Kihean Kim; Sang Joon Lee // Scientific Reports;6/21/2013, p1 

    Cellular uptake pathway of nanoparticle (NP) is different from that of free drugs. Therefore, NP-mediated nanotherapeutics can be designed to overcome the adverse effects of free drugs. However, synthetic NPs are typically trapped in the endosome and have difficulty to reach the cytosol because...

  • Investigation of water-soluble x-ray luminescence nanoparticles for photodynamic activation. Liu, Yuanfang; Chen, Wei; Wang, Shaopeng; Joly, Alan G. // Applied Physics Letters;1/28/2008, Vol. 92 Issue 4, p043901 

    In this letter, we report the synthesis of LaF3:Tb3+–meso-tetra(4-carboxyphenyl) porphine (MTCP) nanoparticle conjugates and investigate the energy transfer as well as singlet oxygen generation following x-ray irradiation. Our observations indicate that LaF3:Tb3+-MTCP nanoparticle...

  • Synthesis and cellular uptake of superparamagnetic dextran-nanoparticles with porphyrinic motifs grafted by esterification. Lucas, Romain; Granet, Robert; Sol, Vincent; Le Morvan, Caroline; Policar, Clotilde; Rivière, Eric; Krausz, Pierre // e-Polymers;Aug2007, p1 

    This paper describes new superparamagnetic nanoparticles bearing dextran-grafted porphyrins with effective cellular uptake properties. They average 110 nm in diameter and are composed of a 5 nm iron oxide core coated with protoporphyrin-grafted dextrans. These particles show good magnetic...

  • Efficiency Of The Photodynamic Therapy Using Gold Nanoparticles (np-Au) And PpIX Induced And Not Induced. Maldonado-Alvarado, Elizabeth; Ramón-Gallegos, Eva; Tánori-Córdova, Judith; Arenas-Huertero, Francisco Jesús; Sánchez-Espíndola, María Esther; Reyes-Arellano, Alicia; Jiménez-Pérez, José Luis; Cruz-Orea, Alfredo // AIP Conference Proceedings;8/11/2008, Vol. 1032 Issue 1, p295 

    The use of gold nanoparticles (np-Au) to eliminate cancer has proved to be very effective due to the fact that cancerous cells accumulate it 600% more than healthy cells. In addition they have a high capacity of absorption and dispersion of light. Therefore, the effectiveness of photodynamic...

  • Signal Transduction and Photodynamic Therapy. Uzdensky, Anatoly B. // Current Signal Transduction Therapy;Jan2008, Vol. 3 Issue 1, p55 

    Photodynamic therapy (PDT), in which stained cells are damaged by light in the presence of oxygen, is now widely used for tumor destruction. Photogenerated singlet oxygen and reactive oxygen species cause oxidative stress and cell death. The potential ROS sensors and following intracellular...

  • Development of Polymeric Cargo for Delivery of Photosensitizer in Photodynamic Therapy. Byoung-chan Bae; Kun Na // International Journal of Photoenergy;2012, Special section p1 

    Photodynamic therapy (PDT), which employs photosensitizers (PSs), a light source with appropriate wavelength, and oxygen molecules, has potential for the treatment of various tumors and nononcological diseases due to its high efficiency in directly producing cellular death, vascular shutdown,...

  • A Novel Magneto-fluorescent Nano-bioprobe for Cancer Cell Targeting, Imaging and Collection. Yicheng Wu; Maoquan Chu; B. Shi; Zonghai Li // Applied Biochemistry & Biotechnology;Apr2011, Vol. 163 Issue 7, p813 

    Silica-coated magnetic polystyrene nanospheres (MPN) containing CdTe/CdS quantum dots (QDs) and FeO nanoparticles were prepared, and novel anti-EGFR antibodies were conjugated onto these magneto-fluorescent nanocomposites (MPN-QDs-SiO) for cancer cell targeting, imaging and collection....

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics