TITLE

Acyl modified chitosan derivatives for oral delivery of insulin and curcumin

AUTHOR(S)
Shelma, R.; Sharma, Chandra P.
PUB. DATE
July 2010
SOURCE
Journal of Materials Science: Materials in Medicine;Jul2010, Vol. 21 Issue 7, p2133
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In the present investigation, bioadhesive property of chitosan (CS) was enhanced by the N-acylation with hexanoyl, lauroyl and oleoyl chlorides. The chemical structure of the modified polymer was characterized by FTIR and zeta potential measurements. The swelling ability was evaluated at alkaline pH. Mucin interactions and mucoadhesion experiments were performed under in vitro experimental conditions. Cytotoxicity experiments were employed to confirm the applicability of these particles as drug carriers. Finally in vitro evaluation of hydrophobic and hydrophilic drug release profile at acidic and alkaline pH was also conducted. A strong interaction between CS acyl derivatives and mucin was detected, which was further confirmed by an in situ mucoadhesion experiments with excised intestinal tissue. CS modified with oleoyl chloride showed better mucoadhesion property, as compared to the one modified with lower fatty acid groups. CS derivatives were found non-toxic on L-929 cell lines and provided sustained release of hydrophobic drugs under in vitro experimental conditions. From these studies it seems that hydrophobically modified CS is an interesting system for drug delivery applications.
ACCESSION #
51931002

 

Related Articles

  • Physical, antibacterial and antioxidant properties of chitosan films incorporated with thyme oil for potential wound healing applications. Altiok, Duygu; Altiok, Evren; Tihminlioglu, Funda // Journal of Materials Science: Materials in Medicine;Jul2010, Vol. 21 Issue 7, p2227 

    Chitosan films incorporated with thyme oil for potential applications of wound dressing were successfully prepared by solvent casting method. The water vapor permeability, oxygen transmission rate, and mechanical properties of the films were determined. Surface and cross-section morphologies and...

  • 3-N-Acylation of 5-Ethoxycarbonyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2-one. Kolosov, M. A.; Orlov, V. D. // Chemistry of Heterocyclic Compounds;Feb2005, Vol. 41 Issue 2, p260 

    Discusses the acetylation of derivatives of 5-ethoxycarbonyl-6methyl-4-phenyl-3,4-dihydropyrimidin-2-one (1) at the N(3) atom. Development of a convenient preparative method for synthesis of 3-acyl derivatives of compound;Consistency of the chemical structure of compound; Mixture of a solution...

  • CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action. Lord, Caleb C.; Betters, Jenna L.; Ivanova, Pavlina T.; Milne, Stephen B.; Myers, David S.; Madenspacher, Jennifer; Thomas, Gwynneth; Chung, Soonkyu; Mingxia Liu; Davis, Matthew A.; Lee, Richard G.; Crooke, Rosanne M.; Graham, Mark J.; Parks, John S.; Brasaemle, Dawn L.; Fessler, Michael B.; Brown, H. Alex; Brown, J. Mark // Diabetes;Feb2012, Vol. 61 Issue 2, p355 

    Mutations of comparative gene identification 58 (CGI-58) in humans cause Chanarin-Dorfman syndrome, a rare autosomal recessive disease in which excess triacylglycerol (TAG) accumulates in multiple tissues. CGI-58 recently has been ascribed two distinct biochemical activities, including...

  • Development and Optimization of Insulin-Chitosan Nanoparticles. Liang Zhao; Chang Su; Bingya Zhu; Yunhong Jia // Tropical Journal of Pharmaceutical Research;Jan2014, Vol. 13 Issue 1, p3 

    Purpose: To optimize the preparation of insulin-chitosan nanoparticles (ICNS) using response surface methodology (RSM). Methods: ICNS were formulated through ionic cross linking method. The effects of the ratio between insulin and chitosan, pH of the medium and rotation speed on insulin...

  • Effect of the Degree of Acetylation of Chitosan on Its Enzymatic Hydrolysis with the Preparation Celloviridin G20kh. Il'ina, A. V.; Varlamov, V. P. // Applied Biochemistry & Microbiology;May/Jun2003, Vol. 39 Issue 3, p239 

    The degree of acetylation was shown to exert only insignificant effects on the enzymatic hydrolysis of chitosan, while affecting the composition of the resulting hydrolysates and their water solubility. Chitosan with various degrees of acetylation was produced by reacetylation of the initial...

  • Synthesis and acylation of O, O-Dihexyl(dioctyl)-[1-hydroxy-3-(ethyl, diethylamino)-2,2-dimethylpropyl]phosphonates. Gazizov, M.; Burangulova, R.; Minnekhanov, R.; Khairullin, R.; Aksenov, N. // Russian Journal of General Chemistry;Jul2013, Vol. 83 Issue 7, p1336 

    Reaction of dialkyl phosphites with 3-ethylamino- or 3-diethylamino-substituted aldehydes results in the corresponding 3-amino-1-hydroxyalkylphosphonates. The composition and structure of the obtained compounds were confirmed by elemental analysis, NMR spectroscopy and chemical transformations.

  • Studies on quinazoline chemistry. 4. Unexpected route of acylation of alkyl 2-(4,4-diphenyl-1,2,3,4-tetrahydro-2-quinazolinylidene)acetates. Molecular structure of methyl 2-(4,4-diphenyl)-1,2,3,4-tetrahydro-2-quinazolinylidene)-3-oxobutanoate. Gromachevskaya, E. V.; Kaigorodova, E. A.; Zavodnik, V. E.; Krapivin, G. D. // Chemistry of Heterocyclic Compounds;Jun2007, Vol. 43 Issue 6, p748 

    A study of the reaction of quinazoline derivatives with acid chlorides in the absence of acids has shown that alkyl 2-(4,4-diphenyl-1,2,3,4-tetrahydro-2-quinazolinylidene)acetates undergo C-acylation. The molecular structure of methyl...

  • Photocurable methacrylate/nanosilica composites. Andrzejewska, Ewa; Sądej, Mariola // Polimery;2008, Vol. 53 Issue 4, p321 

    Two types of photocurable systems containing triethylene glycol dimethacrylate (TEGDM) and 3—15 wt. % of nanosilica were prepared and investigated. The silicas used were structure modified fumed silicas aftertreated by methacrylsilane. The obtained dispersions were characterized by mean...

  • Physicochemical Aspects of Reaction of Ozone with Galactolipid and Galactolipid-Tocopherol Layers. Rudolphi-Skórska, Elżbieta; Filek, Maria; Zembala, Maria // Journal of Membrane Biology;Jul2014, Vol. 247 Issue 7, p639 

    The impact of reaction of galactolipids with ozone on the physicochemical properties of their monolayers was examined. In Megli and Russo (Biochim Biophys Acta, 1778:143-152, ), Cwiklik and Jungwirth (Chem Phys Lett, 486:99-103, ), Jurkiewicz et al. (Biochim Biophys Acta, 1818:2388-2402, ),...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics