TITLE

Friction transfer of polytetrafluoroethylene (PTFE) to produce nanoscale features and influence cellular response in vitro

AUTHOR(S)
Kearns, V. R.; Doherty, P. J.; Beamson, G.; Martin, N.; Williams, R. L.
PUB. DATE
July 2010
SOURCE
Journal of Materials Science: Materials in Medicine;Jul2010, Vol. 21 Issue 7, p2213
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A large number of cell types are known to respond to chemical and topographical patterning of substrates. Friction transfer of polytetrafluoroethylene (PTFE) onto substrates has been shown to produce continuous, straight, parallel nanofibres. Ammonia plasma treatment can be used to defluorinate the PTFE, decreasing the dynamic contact angle. Fibroblast and epithelial cells were elongated and oriented with their long axis parallel to the fibres, both individually and in clusters. The fibres restricted cell migration. Cell alignment was slightly reduced on the plasma-treated fibres. These results indicated that although surface topography can affect cellular response, surface chemistry also mediates the extent of this response.
ACCESSION #
51930994

 

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