TITLE

Simultaneous UV Spectrophotometric Method for Estimation of Paracetamol and Nimesulide in Tablet Dosage Form

AUTHOR(S)
Kirtawade, Rupali; Salve, Pallavi; Seervi, Chhotaram; Kulkarni, Anita; Dhabale, Pandurang
PUB. DATE
April 2010
SOURCE
International Journal of ChemTech Research;Apr2010, Vol. 2 Issue 2, p818
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Paracetamol is an analgesic and antipyretic drug and Nimesulide is an non steroidal anti-inflammatory drug. simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of Paracetamol and Nimesulide in tablet dosage form have been developed. Method employs formation and solving of simultaneous equation using 245.5 nm and 299.5 nm as two analytical wavelengths for both drugs in methanol-Distilled water (50:50). Paracetamol and Nimesulide at their respective λmax 245.5 nm and 299.5 nm shows linearity in a concentration range of 1-11μg /mL and 5-30μg /mL. Recovery studies for Paracetamol 99.56 % and 100.14% for Nimesulide in case of simultaneous equation method confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific.
ACCESSION #
51924366

 

Related Articles

  • UV-visible spectrophotometric simultaneous estimation of paracetamol and nabumetone by AUC method in combined tablet dosage form. Rote, Ambadas R.; Kumbhoje, Prasanna A.; Bhambar, Rajendra S. // Pharmaceutical Methods;Jan-Jun2012, Vol. 3 Issue 1, p40 

    Introduction: The present study deals with development and validation of a simple, rapid, sensitive and economic area under curve method for simultaneous estimation of paracetamol and nabumetone in bulk and tablet dosage form. Materials and Method: Area under curve method includes determination...

  • Simultaneous Spectrophotometric Estimation of Ciprofloxacin and Ornidazole in Tablets. Patel, S. A.; Patel, N. M.; Patel, M. M. // Indian Journal of Pharmaceutical Sciences;2006, Vol. 68 Issue 5, p665 

    Two simple, sensitive, rapid, accurate and economical methods were developed for the estimation of ciprofloxacin and ornidazole in two-component solid dosage form. First method is based on the simultaneous equation, and second method is based on Q-analysis (absorbance ratio method)....

  • Simultaneous Estimation of Nimesulide and Paracetamol in Solid Dosage Form by Rp-Hplc Method. Gharge, Deepali; Dhaba, Pandurang // International Journal of PharmTech Research;Apr2010, Vol. 2 Issue 2, p1330 

    A simple, specific, accurate and precise reverse phase high pressure liquid chromatographic method has been developed for the simultaneous determination of nimesulide and paracetamol from tablets by reverse phase C18 column (HiQsil C18, 250 mm x 4.6 mm). The sample was analyzed using Methanol:...

  • ANALYTICAL METHOD DEVELOPMENT OF REPAGLINIDE IN BULK AND SINGLE COMPONENT FORMULATION. H., Baravaliya Smitaben; G., Tandel Jyotika; Minaxi, Maste; T., Mohite Mukesh // International Journal of Research in Ayurveda & Pharmacy;Jan/Feb2013, Vol. 4 Issue 1, p136 

    Two simple, precise and economical UV methods have been developed for the estimation of Repaglinide in bulk and pharmaceutical formulation Repaglinide absorbance maxima in the zero order derivative spectra was 293nm (Method A) and absorbance maxima in first order derivative spectra was 245nm...

  • Indocid.  // Royal Society of Medicine: Medicines;2002, p302 

    This article provides information on the drug Indocid. The drug is a proprietary, prescription-only preparation of the non-narcotic analgesic and antirheumatic indometacin. It can be used to treat the pain such as that of rheumatic disease and other musculoskeletal disorders, period pain or...

  • Development and Validation of UV-Visible Spectrophotometric Method for Simultaneous Determination of Eperisone and Paracetamol in Solid Dosage Form. Khanage, Shantaram Gajanan; Mohite, Popat Baban; Jadhav, Sandeep // Advanced Pharmaceutical Bulletin;Jun2013, Vol. 3 Issue 2, p447 

    Purpose: Eperisone Hydrochloride (EPE) is a potent new generation antispasmodic drug which is used in the treatment of moderate to severe pain in combination with Paracetamol (PAR). Both drugs are available in tablet dosage form in combination with a dose of 50 mg for EPE and 325 mg PAR...

  • Simultaneous Spectrophotometric Estimation of Paracetamol and Metoclopramide Hydrochloride in Solid Dosage Form. WADHER, S. J.; PATHANKAR, P. R.; PURANIK, MANISHA; GANJIWALE, R. O.; YEOLE, P. G. // Indian Journal of Pharmaceutical Sciences;2008, Vol. 70 Issue 3, p393 

    Two simple, accurate, rapid and economical spectrophotometric methods have been developed for the simultaneous determination of paracetamol and metoclopramide hydrochloride from tablet dosage form. The first method developed employs formation and solving simultaneous equations using 248.6 nm and...

  • COMPARATIVE ASSESSMENT OF THE QUALITY MEASUREMENT OF SOME COMMERCIALLY AVAILABLE PARACETAMOL TABLETS. Giri, Tapan Kumar; Barwey, Nandini; Verma, Saurabh; Alexander, Amit; Ajazuddin; Badwaik, Hemant; Tripathi, Dulal Krishna // International Journal of Pharmaceutical Sciences Review & Resear;May/Jun2012, Vol. 14 Issue 2, p42 

    The study assessment the quality of different brands of paracetamol tablets soured from medical representatives from different pharmaceutical manufactures in India by evaluating their pharmaceutical and chemical equivalence in order to determine their interchangeability. The physiochemical...

  • Simultaneous Spectrophotometric Estimation of Gatifloxacin and Ornidazole in Tablet Dosage Form. Paramane, Sonali; Kothapalli, Lata; Thomas, Asha; Deshpande, A. D. // Indian Journal of Pharmaceutical Sciences;2006, Vol. 68 Issue 6, p819 

    Three simple, accurate and economic methods multicomponent, two wavelength and simultaneous equations using area under curve have been described for the simultaneous determination of gatifloxacin and ornidazole in tablet dosage form. Gatifloxacin shows absorption maximum at 287.5 nm and...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics