Simultaneous UV Spectrophotometric Method for Estimation of Paracetamol and Nimesulide in Tablet Dosage Form

Kirtawade, Rupali; Salve, Pallavi; Seervi, Chhotaram; Kulkarni, Anita; Dhabale, Pandurang
April 2010
International Journal of ChemTech Research;Apr2010, Vol. 2 Issue 2, p818
Academic Journal
Paracetamol is an analgesic and antipyretic drug and Nimesulide is an non steroidal anti-inflammatory drug. simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of Paracetamol and Nimesulide in tablet dosage form have been developed. Method employs formation and solving of simultaneous equation using 245.5 nm and 299.5 nm as two analytical wavelengths for both drugs in methanol-Distilled water (50:50). Paracetamol and Nimesulide at their respective λmax 245.5 nm and 299.5 nm shows linearity in a concentration range of 1-11μg /mL and 5-30μg /mL. Recovery studies for Paracetamol 99.56 % and 100.14% for Nimesulide in case of simultaneous equation method confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific.


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