TITLE

Pre-stimulation parameters predicting live birth after IVF in the long GnRH agonist protocol

AUTHOR(S)
Pettersson, Göran; Andersen, Anders Nyboe; Broberg, Per; Arce, Joan-Caries
PUB. DATE
May 2010
SOURCE
Reproductive BioMedicine Online (Reproductive Healthcare Limited;May2010, Vol. 20 Issue 5, p572
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This retrospective study aimed to identify novel pre-stimulation parameters associated with live birth in IVF and to develop a model for prediction of the chances of live birth at an early phase of the treatment cycle. Data were collected from a randomized trial in couples with unexplained infertility, tubal factor, mild male factor or other reason for infertility. All women (n = 731) had undergone an IVF cycle (no intracytoplasmic sperm injection) after stimulation with human menopausal gonadotrophin or follicle-stimulating hormone following the long gonadotrophin-releasing hormone agonist protocol. The univariate tests identified several novel parameters that were significantly (P < 0.05) associated with live birth (duration of agonist use, endometrial thickness, pre-stimulation progesterone, androstenedione and total testosterone concentrations, pre-stimulation free androgen index and primary infertility diagnosis), in addition to the well-known predictors female age and duration of infertility. Using multivariable logistic regression analysis, the best predictive model (area under the curve = 0.65) was obtained using the parameters age, duration of infertility, infertility diagnosis, endometrial thickness and pre-stimulation total testosterone and sex hormone-binding globulin concentrations. The results indicate that younger age and marked suppression of ovarian steroids prior to starting stimulation may increase the livelihood of live birth in the long protocol
ACCESSION #
51917617

 

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