TITLE

Risk-Adapted Anastomosis for Partial Pancreaticoduodenectomy Reduces the Risk of Pancreatic Fistula: A Pilot Study

AUTHOR(S)
Niedergethmann, Marco; Dusch, Niloufar; Widyaningsih, Rizky; Weiss, Christel; Kienle, Peter; Post, Stefan
PUB. DATE
July 2010
SOURCE
World Journal of Surgery;Jul2010, Vol. 34 Issue 7, p1579
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Pancreatic fistula (PF) is the main cause of postoperative morbidity and mortality after pancreatectomy. Two reasons for PF are a “soft” pancreatic texture and a narrow pancreatic duct (high-risk gland). Pancreaticojejunostomy (PJ) may lead to a higher fistula rate in such glands. In the literature there are no data available on risk-adapted assignment of pancreatogastrostomy (PG) in a high-risk gland. Therefore, an observational pilot study was conducted to address this issue. Since January 2007 the concept of a “risk-adapted pancreatic anastomosis” (RAP) was introduced (PG for high-risk glands). The PF rate, morbidity, and mortality during this period (January 2007 to December 2008, n = 74) were compared to those between January 2004 and December 2006 ( n = 119, only PJ). PF was defined according to the International Study Group on Pancreatic Surgery. Through RAP the PF rate was reduced from 22 to 11% ( P = 0.0503). Grade C PF rate was reduced from 6.7 to 1.4% ( P = 0.1569) and grade A PF from 6 to 1.4% ( P = 0.2537). The PF-associated mortality was reduced from 3.4 to 1.4%. PG revealed a PF rate of 7% and PJ accounted for 19% of PFs ( P = 0.1765). There was no incidence of grade C PF following PG. The incidence of intraluminal hemorrhage ( P = 0.0422) and delayed gastric emptying ( P = 0.0572) was higher following PG. The rate of PF could be significantly reduced with the use of RAP. One should be cautious about the indication for PG, since it is associated with a higher rate of intraluminal hemorrhage and delayed gastric emptying. There are no long-term results on PG with respect to its durability and function. A general recommendation for its use cannot currently be made.
ACCESSION #
51880561

 

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