TITLE

Preoperative Radiochemotherapy in T3 Operable Low Rectal Cancers: A Gold Standard?

AUTHOR(S)
Fucini, Claudio; Pucciani, Filippo; Elbetti, Claudio; Gattai, Riccardo; Russo, Antonio
PUB. DATE
July 2010
SOURCE
World Journal of Surgery;Jul2010, Vol. 34 Issue 7, p1609
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Preoperative chemoradiation followed by total mesorectal excision (TME) has become a standard treatment of preoperatively staged T3 low rectal cancers in many institutions; however, a direct comparison of generalized preoperative versus selective adjuvant chemoradiation has never been assessed in a clinical practice setting. Over a 4-year period, 80 patients with T3 primary low adenocarcinoma of the rectum, judged operable at preoperative staging, were offered preoperative chemoradiation. Forty-seven patients (Group I) accepted the neoadjuvant treatment and 33 (Group II) preferred immediate surgery and postoperative chemoradiation if indicated. Major postoperative complications occurred in 21% of Group I versus in 11% of Group II ( p = 0.3) patients. After a mean follow-up of 92 months, the local recurrence rate was 4 and 9% ( p = 0.4), metastasis rate was 30 and 24% ( p = 0.5), 5-year survival probability was 0.79 (95% CI = 0.49–0.92) and 0.82 (95% CI = 0.70–1.00) (log-rank test, p = 0.6) for Group I and Group II, respectively. In T3 operable low rectal cancers, selective postoperative radiochemotherapy yielded similar long-term results regarding recurrence rate and survival as extended preoperative chemoradiation.
ACCESSION #
51880526

 

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