TITLE

Expression of Hepatocyte Growth Factor Activator Inhibitor Type 1 in Human Hepatocellular Carcinoma and Postoperative Outcomes

AUTHOR(S)
Funagayama, Mayumi; Kondo, Kazuhiro; Chijiiwa, Kazuo; Kataoka, Hiroaki
PUB. DATE
July 2010
SOURCE
World Journal of Surgery;Jul2010, Vol. 34 Issue 7, p1563
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Hepatocyte growth factor activator inhibitor type 1 (HAI-1), one of the Kunitz-type serine protease inhibitors, has an important role in cancer progression through regulation of the activity of hepatocyte growth factor. HAI-1 is expressed in hepatocellular carcinoma (HCC) to various degrees. Investigation of the relationship between HAI-1 expression and clinicopathological features of HCC may contribute to improved treatment outcomes for HCC through understanding the mechanism of tumor progression or improvement in the prediction of tumor malignancy. The study included 121 HCC patients treated surgically from 1996 to 2005. We performed immunohistological examination for HAI-1 in resected HCC specimens by use of anti-human HAI-1 monoclonal antibody. Clinicopathological features, including postoperative overall survival (OS) and disease-free survival (DFS) rates, were compared between the immunoreaction positive and negative groups. The immunoreaction positive group included 38 patients (31%), and the negative group included 83 patients (69%). OS and DFS rates were significantly higher in the HAI-1 negative group than in the positive group. HAI-1 positivity related to multiplicity, vascular invasion, and characteristics of advanced tumor stage. In multivariate analysis, expression of HAI-1 was a significant independent prognostic tumor factor. Expression of HAI-1 in HCC cells is associated with poor prognosis for HCC patients. HAI-1 may be important in HCC progression and may be a new prognostic factor for HCC.
ACCESSION #
51880524

 

Related Articles

  • Targeting MET in cancer: rationale and progress. Gherardi, Ermanno; Birchmeier, Walter; Birchmeier, Carmen; Woude, George Vande // Nature Reviews Cancer;Feb2012, Vol. 12 Issue 2, p89 

    Uncontrolled cell survival, growth, angiogenesis and metastasis are essential hallmarks of cancer. Genetic and biochemical data have demonstrated that the growth and motility factor hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the tyrosine kinase MET, have a causal role in...

  • In Vivo Detection of c-MET Expression in a Rat Hepatocarcinogenesis Model Using Molecularly Targeted Magnetic Resonance Imaging. Towner, Rheal A.; Smith, Nataliya; Tesiram, Yasvir A.; Abbott, Andrew; Saunders, Debbie; Blindauer, Rebecca; Herlea, Oana; Silasi-Mansat, Robert; Lupu, Florea // Molecular Imaging;Jan/Feb2007, Vol. 6 Issue 1, p18 

    The multifunctional growth factor scatter factor/hepatocyte growth factor and its tyrosine kinase receptor, c-MET, have been implicated in the genesis and malignant progression of numerous human malignancies, including hepatocellular carcinomas. The incidence of hepatocellular carcinomas in the...

  • Estrogen Suppresses Metastasis in Rat Hepatocellular Carcinoma through Decreasing Interleukin-6 and Hepatocyte Growth Factor Expression. Wang, Yong-Cang; Xu, Ge-Liang; Jia, Wei-Dong; Han, Sheng-Jin; Ren, Wei-Hua; Wang, Wei; Liu, Wen-Bin; Zhang, Chuan-Hai; Chen, Hao // Inflammation;Feb2012, Vol. 35 Issue 1, p143 

    Metastasis remains one of the major challenges before hepatocellular carcinoma (HCC) is finally conquered. Estrogen has recently emerged as a protective factor in the development and progression of HCC, but whether and how it reduces metastasis of HCC remain to be elucidated. We conducted an in...

  • An uncleavable form of pro--scatter factor suppresses tumor growth and dissemination in mice. Mazzone, Massimiliano; Basilico, Cristina; Cavassa, Silvia; Pennacchietti, Selma; Risio, Mauro; Naldini, Luigi; Comoglio, Paolo M.; Michieli, Paolo // Journal of Clinical Investigation;Nov2004, Vol. 114 Issue 10, p1418 

    Scatter factor (SF), also known as hepatocyte growth factor, is ubiquitously present in the extracellular matrix of tissues in the form of an inactive precursor (pro-SF). In order to acquire biological activity, pro-SF must be cleaved by specific proteases present on the cell surface. The mature...

  • Induction of tumor initiation is dependent on CD44s in c-Met+ hepatocellular carcinoma. Hien Dang; Steinway, Steven N.; Wei Ding; Rountree, Carl B. // BMC Cancer;2015, Vol. 15 Issue 1, p1 

    Background: Hepatocellular carcinoma (HCC) patients with active hepatocyte growth factor (HGF)/c-Met signaling have a significantly worse prognosis. c-Met, a high affinity receptor for HGF, plays a critical role in cancer growth, invasion and metastasis. c-Met and CD44 have been utilized as cell...

  • MACC1 as a Prognostic Biomarker for Early-Stage and AFP-Normal Hepatocellular Carcinoma Xie, Chan; Wu, Jueheng; Yun, Jingping; Lai, Jiaming; Yuan, Yunfei; Gao, Zhiliang; Li, Mengfeng; Li, Jun; Song, Libing // PLoS ONE;May2013, Vol. 8 Issue 5, p1 

    Background: The metastasis-associated in colon cancer 1 gene (MACC1) has been found to be associated with cancer development and progression. The aim of this study was to investigate the prognostic value of MACC1 in early-stage and AFP-normal hepatocellular carcinoma (HCC). Methods: mRNA and...

  • Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis. Yu-Wen Zhang; Ling-Mei Wang; Jove, Richard; Vande Woude, George F. // Oncogene;1/10/2002, Vol. 21 Issue 2, p217 

    Deals with a study which investigated the requirement of Stat3 signaling for Hepatocyte Growth Factor/Scatter Factor (HGF/SF)-Met mediated tumorigenesis. Information on HGF/SF; Methodology of the study; Results and discussion.

  • Role of the Stem Domain of Matriptase in the Interaction with its Physiological Inhibitor, Hepatocyte Growth Factor Activator Inhibitor Type I. Kojima, Kenji; Tsuzuki, Satoshi; Fushiki, Tohru; Inouye, Kuniyo // Journal of Biochemistry;Jun2009, Vol. 145 Issue 6, p783 

    Matriptase is a type II transmembrane serine protease containing the non-catalytic domains (stem domain) and catalytic domain in the extra-cellular region. Our aim is to address the role of the stem domain in the interaction between matriptase and its physiological inhibitor, hepatocyte growth...

  • The five amino acid-deleted isoform of hepatocyte growth factor promotes carcinogenesis in transgenic mice. Bell, Aaron; Chen, Qiuyan; DeFrances, Marie C; Michalopoulos, George K; Zarnegar, Reza // Oncogene;1/28/99, Vol. 18 Issue 4, p887 

    Hepatocyte growth factor (HGF) is a polypeptide with mitogenic, motogenic, and morphogenic effects on different cell types including hepatocytes. HGF is expressed as two biologically active isotypes resulting from alternative RNA splicing. The roles of each HGF isoform in development, liver...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics