TITLE

Synchrotron microangiography studies of angiogenesis in mice with microemulsions and gold nanoparticles

AUTHOR(S)
Chia-Chi Chien; Wang, C. H.; Wang, C. L.; Li, E. R.; Lee, K. H.; Hwu, Y.; Lin, Chien-Yi; Shing-Jyh Chang; Yang, C. S.; Petibois, Cyril; Margaritondo, G.
PUB. DATE
July 2010
SOURCE
Analytical & Bioanalytical Chemistry;Jul2010, Vol. 397 Issue 6, p2109
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We present an effective solution for the problem of contrast enhancement in phase-contrast microangiography, with the specific objective of visualising small (<8 µm) vessels in tumor-related microangiogenesis. Different hydrophilic and hydrophobic contrast agents were explored in this context. We found that an emulsified version of the hydrophobic contrast agents Lipiodol® provides the best contrast and minimal distortion of the circulation and vessel structure. Such emulsions are reasonably biocompatible and, with sizes of 0 ± 0.8 µm, sufficient to diffuse to the smallest vessel and still provide reasonable contrast. We also explored the use of Au nanoparticle colloids that could be used not only to enhance contrast but also for interesting applications in nanomedicine. Both the Lipiodol microemulsions and Au nanoparticle colloids can be conjugated with medicines or cell specific labeling agents and their small size can allow the study of the diffusion of contrast agents through the vessel leakage. This enables direct imaging of drug delivery which is important for cancer treatment. [Figure not available: see fulltext.]
ACCESSION #
51880427

 

Related Articles

  • Tracking Dynamic Microvascular Changes during Healing after Complete Biopsy Punch on the Mouse Pinna Using Optical Microangiography. Jung, Yeongri; Dziennis, Suzan; Zhi, Zhongwei; Reif, Roberto; Zheng, Ying; Wang, Ruikang K. // PLoS ONE;Feb2013, Vol. 8 Issue 2, p1 

    Optical microangiography (OMAG) and Doppler optical microangiography (DOMAG) are two non-invasive techniques capable of determining the tissue microstructural content, microvasculature angiography, and blood flow velocity and direction. These techniques were used to visualize the acute and...

  • Laser-targeted angiography may aid ARMD. Charters, Lynda // Ophthalmology Times;1/15/97, Vol. 22 Issue 2, p1 

    Reveals that laser-targeted angiography may highlight choroidal neovascularization (CNV) in rats in a manner not possible with conventional fluorescein angiography. Enabling of visualization of occult new vessels and their flow patterns; Use as guide to photocoagulative treatment.

  • Triamcinolone.  // Reactions Weekly;6/16/2007, Issue 1156, p26 

    The article presents the case of an 84-year-old man who developed toxoplasmosis retinochroiditis after intravitreal triamcinolone administration. He suffered decreased central vision in his left eye for a period of seven days. A yellow-white juxtafoveal lesion with intense leakafe and late...

  • Bevacizumab.  // Reactions Weekly;9/1/2007, Issue 1167, p8 

    The article presents a case study of 22 elderly patients aged between 65 and 93 years who have developed retinal pigment epithelial tears (RPE) after administration of intravitreal bevacizumab for age-related macular degeneration. The presence or absence of RPE tears and prior pigment epithelial...

  • Putnam Hospital Center opens new angiography suite.  // Hudson Valley Business Journal;4/26/2010, Vol. 21 Issue 17, p21 

    The article offers information on the installation of the Angiography Suite at Putnam Hospital Center in Putnam County, New York to provide clinical applications with high resolution of radiology procedures.

  • Top down bottom up: Perfect match.  // Nature Nanotechnology;Dec2009, Vol. 4 Issue 12, p793 

    The article discusses research on gold nanoparticles, it references a study by Mathias Brust and colleagues, published within the issue.

  • Physical Review Letters: The finest gold dust in the world.  // Biomedical Market Newsletter;6/1/2012, Vol. 21, p1 

    The article offers information on the technology developed by scientists at the Vienna University of Technology for creation of nano gold particles.

  • Self-assembly of nanoparticles into structured spherical and network aggregates. Boal, Andrew K.; Ilhan, Faysal // Nature;4/13/2000, Vol. 404 Issue 6779, p746 

    Discusses the polymer-mediated `bricks-and-mortar' strategy for the self-assembly of nanoparticles into structured spherical and network aggregates. Self-assembly of monolayer-protected gold particles into nanostructures; Potential of the method in the formation of structures such as rods and...

  • Gold nanoparticles as high-resolution X-ray imaging contrast agents for the analysis of tumor-related micro-vasculature.  // Journal of Nanobiotechnology;2012, Vol. 10 Issue 1, p10 

    The article offers information on the study regarding angiogenesis which is widely investigated in conjunction with cancer development, in particular because of the possibility of early stage detection and of new therapeutic strategies. It is mentioned that these kind of studies are negatively...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics