TITLE

Structural and micro-anatomical changes in vertebrae associated with idiopathic-type spinal curvature in the curveback guppy model

AUTHOR(S)
Gorman, Kristen F.; Handrigan, Gregory R.; Ge Jin; Wallis, Rob; Breden, Felix
PUB. DATE
January 2010
SOURCE
Scoliosis (17487161);2010, Vol. 5, p10
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The curveback lineage of guppy is characterized by heritable idiopathic-type spinal curvature that develops during growth. Prior work has revealed several important developmental similarities to the human idiopathic scoliosis (IS) syndrome. In this study we investigate structural and histological aspects of the vertebrae that are associated with spinal curvature in the curveback guppy and test for sexual dimorphism that might explain a female bias for severe curve magnitudes in the population. Methods: Vertebrae were studied from whole-mount skeletal specimens of curved and non-curved adult males and females. A series of ratios were used to characterize structural aspects of each vertebra. A three-way analysis of variance tested for effects of sex, curvature, vertebral position along the spine, and all 2-way interactions (i.e., sex and curvature, sex and vertebra position, and vertebra position and curvature). Histological analyses were used to characterize microarchitectural changes in affected vertebrae and the intervertebral region. Results: In curveback, vertebrae that are associated with curvature demonstrate asymmetric shape distortion, migration of the intervertebral ligament, and vertebral thickening on the concave side of curvature. There is sexual dimorphism among curved individuals such that for several vertebrae, females have more slender vertebrae than do males. Also, in the region of the spine where lordosis typically occurs, curved and non-curved females have a reduced width at the middle of their vertebrae, relative to males. Conclusions: Based on similarities to human spinal curvatures and to animals with induced curves, the concaveconvex biases described in the guppy suggest that there is a mechanical component to curve pathogenesis in curveback. Because idiopathic-type curvature in curveback is primarily a sagittal deformity, it is structurally more similar to Scheuermann kyphosis than IS. Anatomical differences between teleosts and humans make direct biomechanical comparisons difficult. However, study of basic biological systems involved in idiopathic-type spinal curvature in curveback may provide insight into the relationship between a predisposing aetiology, growth, and biomechanics. Further work is needed to clarify whether observed sex differences in vertebral characteristics are related to the female bias for severe curves that is observed in the population.
ACCESSION #
51863779

 

Related Articles

  • A new method for measuring torsional deformity in scoliosis. Doi, Toshio; Kido, Satoshi; Kuwashima, Umito; Tono, Osamu; Tarukado, Kiyoshi; Harimaya, Katsumi; Matsumoto, Yoshihiro; Kawaguchi, Kenichi; Iwamoto, Yukihide // Scoliosis (17487161);2011, Vol. 6 Issue 1, p7 

    Background: The importance of spinal rotational and torsional deformity in the etiology and the management of scoliosis are well-recognized. For measuring the posterior spinal component rotation, Ho's method was reported to be reliable. However, there is no practical method to measure the...

  • A New Look at Adolescent Idiopathic Scoliosis. Sanna, Mark // American Chiropractor;Apr2009, Vol. 31 Issue 4, p18 

    The article discusses the adolescent idiopathic scoliosis (AIS), which is an abnormal lateral curve to the vertebrae column. The author explains that most types of scoliosis are sorted out into classes and notes that this type of deformity of the spine is not yet known. Assumptions on the...

  • Relative anterior spinal overgrowth in adolescent idiopathic scoliosis�result of disproportionate endochondral-membranous bone growth? Guo, X.; Chau, W-W.; Chan, Y-L.; Cheng, J-C-Y.; Burwell, R.G.; Dangerfield, P.H. // European Spine Journal;Dec2005, Vol. 14 Issue 9, p862 

    There is no generally accepted scientific theory for the etiology of adolescent idiopathic scoliosis (AIS). As part of its mission to widen understanding of scoliosis etiology, the International Federated Body on Scoliosis Etiology (IBSE) introduced the electronic focus group (EFG) as a means of...

  • The internal pressure and stress environment of the scoliotic intervertebral disc – a review. Meir, A.; McNally, D. S.; Fairbank, J. C.; Jones, D.; Urban, J. P. // Proceedings of the Institution of Mechanical Engineers -- Part H;Feb2008, Vol. 222 Issue 2, p209 

    The aetiology, in terms of both initiation and progression, of the deformity in idiopathic scoliosis is at present unclear. Even in neuromuscular cases, the mechanisms underlying progression are not fully elucidated. It is thought, however, that asymmetrical loading is involved in the...

  • Abstracts for Oral Presentations for EuroSpine 2012, May Amsterdam.  // European Spine Journal;May2012, Vol. 21, p269 

    The article presents abstracts on medical topics including fibrous dysplasia of the spine, etiology of Adolescent Idiopathic Scoliosis (AIS), and treatment of progressive spinal deformities.

  • Molecular analysis of congenital scoliosis: a candidate gene approach. Maisenbacher, Melissa; Ji-Soo Han; O'Brien, Megan; Tracy, Michael; Erol, Bülent; Schaffer, Alyssa; Dormans, John; Zackai, Elaine; Kusumi, Kenro // Human Genetics;Apr2005, Vol. 116 Issue 5, p416 

    The etiology of congenital scoliosis is largely unknown. The severe vertebral disorder, spondylocostal dysostosis type 1, is associated with a homozygous delta-like 3 (DLL3) mutation. Scoliosis has been observed in a heterozygousDLL3carrier, raising the possibility of its involvement in...

  • Scoliosis: a review. Goldberg, Caroline J.; Moore, David P.; Fogarty, Esmond E.; Dowling, Frank E. // Pediatric Surgery International;Feb2008, Vol. 24 Issue 2, p129 

    Scoliosis, lateral curvature of the spine, has been studied since Hippocrates’ time, but remains a disputed subject in orthopaedic surgery, because of its several varieties, unknown cause and unpredictable course. A review of 30 years’ experience in a paediatric orthopaedic unit...

  • Motor cortical hyperexcitability in idiopathic scoliosis: could focal dystonia be a subclinical etiological factor? Doménech, Julio; Tormos, José María; Barrios, Carlos; Pascual-Leone, Alvaro // European Spine Journal;Feb2010, Vol. 19 Issue 2, p223 

    The aetiology of idiopathic scoliosis (IS) remains unknown; however, there is a growing body of evidence suggesting that the spine deformity could be the expression of a subclinical nervous system disorder. A defective sensory input or an anomalous sensorimotor integration may lead to an...

  • Indication for preoperative MRI of neural axis abnormalities in patients with presumed thoracolumbar/lumbar idiopathic scoliosis. Qiao, Jun; Zhu, Zezhang; Zhu, Feng; Wu, Tao; Qian, Bangping; Xu, Leiei; Qiu, Yong // European Spine Journal;Feb2013, Vol. 22 Issue 2, p360 

    Purpose: The purpose of this study was to investigate the incidence of neural axis abnormalities in patients with presumed 'idiopathic' thoracolumbar or lumbar scoliosis by magnetic resonance imaging (MRI) and try to determine which clinical and radiographic characteristics correlate with neural...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics