Treatment of Severe Acute Respiratory Distress Syndrome: A Final Report on a Phase I Study

Hardaway, Robert M.; Harke, Henning; Tyroch, Alan H.; Williams, Charles H.; Vazquez, Yvonne; Krause, Gary F.
April 2001
American Surgeon;Apr2001, Vol. 67 Issue 4, p377
Academic Journal
Adult respiratory distress syndrome (ARDS) has a high mortality. Its only effective treatment is respiratory therapy. If this fails mortality is probably 100 per cent. No other treatment for ARDS has proved effective including "magic bullets." Twenty patients suffering from ARDS secondary to trauma and/or sepsis failed to respond to treatment with mechanical ventilation and positive end-expiratory pressure. On the assumption that disseminated intravascular coagulation initiates ARDS by occluding the pulmonary microcirculation with microclots, the patients were treated with plasminogen activators. The patients responded with significant improvement in partial pressure of oxygen in arterial blood. No bleeding occurred and clotting parameters remained normal. We conclude that ARDS can be safely treated with plasminogen activator.


Related Articles

  • Surgical Education and Self-assessment Program (SESAP).  // Canadian Journal of Surgery;Feb2004, Vol. 47 Issue 1, p56 

    Presents Surgical Education and Self-Assessment Program question and critique about the use of adjunctive therapy for acute lung injury and acute respiratory distress syndrome. Adjunctive therapy that has a beneficial effect on survival from acute lung injury and the acute respiratory distress...

  • A new weapon against ARDS. Angelucci, Patricia // RN;Nov96, Vol. 59 Issue 11, p22 

    Investigates the effectiveness of using nitric oxide gas therapy on patients with adult respiratory distress syndrome (ARDS). Mechanism of action of nitric oxide; Administration; Reduction of the risk of therapy; Precautions; Importance of monitoring the methemoglobin levels and signs of...

  • Pelargonium sidoides extract EPs 7630: a review of its clinical efficacy and safety for treating acute respiratory tract infections in children. Careddu, Domenico; Pettenazzo, Andrea // International Journal of General Medicine;Mar2018, Vol. 11, p91 

    Background: In numerous randomized controlled trials (RCTs) and systematic reviews such as those published by the Cochrane Collaboration, Pelargonium sidoides extract EPs® 7630 was shown to be effective in acute respiratory tract infections (aRTI) in all investigated age-groups. This...

  • Clinical Study of Critical Patients with Hemorrhagic Fever with Renal Syndrome Complicated by Acute Respiratory Distress Syndrome. Du, Hong; Li, Jing; Jiang, Wei; Yu, Haitao; Zhang, Ye; Wang, Junning; Wang, Pingzhong; Bai, Xuefan // PLoS ONE;Feb2014, Vol. 9 Issue 2, p1 

    Objectives: The aim of this study was to investigate the clinical characteristics and outcomes of critical patients with hemorrhagic fever with renal syndrome (HFRS) complicated by acute respiratory distress syndrome (ARDS). Materials and Methods: To observe the demographic, epidemiological and...

  • Extracorporeal membrane oxygenation in burn patients with refractory acute respiratory distress syndrome leads to 28 % 90-day survival. Soussi, Sabri; Gallais, Pauline; Kachatryan, Levon; Benyamina, Mourad; Ferry, Axelle; Cupaciu, Alexandru; Chaussard, Maïté; Maurel, Véronique; Chaouat, Marc; Mimoun, Maurice; Mebazza, Alexandre; Legrand, Matthieu; Chaussard, Maïté; Maurel, Véronique; PRONOBURN Group // Intensive Care Medicine;Nov2016, Vol. 42 Issue 11, p1826 

    The article examines the effectiveness of extracorporeal membrane oxygenation (ECMO) and its impact to the survivability of burn patients with refractory acute respiratory distress syndrome (ARDS). The author highlights the research that seeks to report ECMO usage in the medical practice for the...

  • Extracorporeal Membrane Oxygenation as a First-Line Treatment Strategy for ARDS: Is the Evidence Sufficiently Strong? Checkley, William // JAMA: Journal of the American Medical Association;10/19/2011, Vol. 306 Issue 15, p1703 

    The author looks at the use of extracorporeal membrane oxygenation (ECMO) as early treatment for acute respiratory distress syndrome (ARDS). He references a study by M. A. Noah et al. published within the issue. He cites that the study suggests that the use of ECMO can be immediately established...

  • Glucocorticoid therapy in acute respiratory distress syndrome. Gibbs, R. H. // British Journal of Hospital Medicine (17508460);Nov2009, Vol. 70 Issue 11, p665 

    The article discusses the management of acute respiratory distress syndrome (ARDS) with glucocorticoids. It is noted that only moderate doses of glucocorticoids will achieve the desired therapeutic effects which improves the overall physiological functioning of the heart and lungs. However,...

  • Corticosteroids in treatment of aspiration-related acute respiratory distress syndrome: results of a retrospective cohort study. Jiang-nan Zhao; Yao Liu; Huai-chen Li; Zhao, Jiang-Nan; Liu, Yao; Li, Huai-Chen // BMC Pulmonary Medicine;2/10/2016, Vol. 16, p1 

    Background: Acute stroke patients suffering from aspiration may present with acute respiratory distress syndrome (ARDS). There is still a lack of convincing data about the efficacy of corticosteroids in the treatment of aspiration-related ARDS. Therefore, we evaluated the clinical...

  • Utilisation of high-frequency oscillatory ventilation in blunt thoracic trauma. Scarborough, John E; Vaslef, Steven N // Trauma;Oct2010, Vol. 12 Issue 4, p247 

    No abstract available.

  • Improving oxygenation in a patient with ARDS. Dale, David C.; Federman, Daniel D. // Cortlandt Forum;05/25/97, Vol. 10 Issue 5, p25 

    Describes a method of improving oxygenation in a patient with acute respiratory distress syndrome (ARDS). Placing the patient in the prone position; Increase in arterial oxygen tension.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics