TITLE

Treatment of Severe Acute Respiratory Distress Syndrome: A Final Report on a Phase I Study

AUTHOR(S)
Hardaway, Robert M.; Harke, Henning; Tyroch, Alan H.; Williams, Charles H.; Vazquez, Yvonne; Krause, Gary F.
PUB. DATE
April 2001
SOURCE
American Surgeon;Apr2001, Vol. 67 Issue 4, p377
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Adult respiratory distress syndrome (ARDS) has a high mortality. Its only effective treatment is respiratory therapy. If this fails mortality is probably 100 per cent. No other treatment for ARDS has proved effective including "magic bullets." Twenty patients suffering from ARDS secondary to trauma and/or sepsis failed to respond to treatment with mechanical ventilation and positive end-expiratory pressure. On the assumption that disseminated intravascular coagulation initiates ARDS by occluding the pulmonary microcirculation with microclots, the patients were treated with plasminogen activators. The patients responded with significant improvement in partial pressure of oxygen in arterial blood. No bleeding occurred and clotting parameters remained normal. We conclude that ARDS can be safely treated with plasminogen activator.
ACCESSION #
5181340

 

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