TITLE

Effect of Pneumoperitoneal Pressure on Tumor Dissemination and Tumor Recurrence at Port-Site and Midline Incisions

AUTHOR(S)
Moreira Jr., Helio; Yamaguchi, Takuyu; Wexner, Steven; Zhao, Ronghua; Baig, Mirza Khurrum; Singer, Lisa; Mack, Judith A.; Xiong, Hui; Abramson, Susan
PUB. DATE
April 2001
SOURCE
American Surgeon;Apr2001, Vol. 67 Issue 4, p369
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Over the past several years numerous cases of port site tumor recurrence after laparoscopic resection of a cancerous tissue have been reported. Possible mechanisms for tumor seeding include tumor removal, contaminated instruments, pneumoperitoneum, and aerosolization of tumor cells. This experiment examined the relationship among trocar contamination, aerosolization, and tumor recurrence with increasing pneumoperitoneal pressure using a hamster model. Increased pneumoperitoneal pressure significantly increased both instrument contamination and tumor recurrence at midline and port site incisions. Interestingly, increasing pneumoperitoneal pressure had no significant effect on the number of aerosolized tumor cells. The results reaffirm that the use of a reduced pneumoperitoneum or gasless laparoscopy may significantly lower port site tumor recurrence.
ACCESSION #
5181336

 

Related Articles

  • Development of a novel animal model to differentiate radiation necrosis from tumor recurrence. Kumar, Sanath; Arbab, Ali; Jain, Rajan; Kim, Jinkoo; deCarvalho, Ana; Shankar, Adarsh; Mikkelsen, Tom; Brown, Stephen // Journal of Neuro-Oncology;Jul2012, Vol. 108 Issue 3, p411 

    Distinguishing tumor progression from radiation necrosis after treatment in patients with brain tumors presents a clinical dilemma. A well-characterized, orthotopic rodent model of radiation-induced brain necrosis including a tumor is not currently available The objective of the study was to...

  • Numerical experiments with model equations of cancer invasion of tissue. Kolev, Mikhail; Zubik-Kowal, Barbara // Control & Cybernetics;2011, Vol. 40 Issue 3, p779 

    In this paper we investigate a mathematical model of cancer invasion of tissue, which incorporates haptotaxis, chemotaxis, proliferation and degradation rates for cancer cells and the extracellular matrix, kinetics of urokinase receptor, and urokinase plasminogen activator cycle. We solve the...

  • Compound Composite Odontome associated with Partial Anodontia - A Case Report. Bhoomika D. W.; Singh, D.; Nganba, K.; Priyanka // Journal of Dental Specialities;Feb2014, Vol. 2 Issue 1, p41 

    Odontomes are hamartomatous lesions or hard tissue anomalies rather than true neoplasm. They are asymptomatic frequently associated with delayed tooth eruption and often diagnosed in the second decade of life. This case report discusses the presence of multiple tooth like structures in the upper...

  • Interactions between microenvironment and cancer cells in two animal models of bone metastasis. Blouin, S; Baslé, M F; Chappard, D; Baslé, M F // British Journal of Cancer;2/26/2008, Vol. 98 Issue 4, p809 

    The preferential proliferation of cancer cells in the bone microenvironment is poorly characterised. Expression pattern of bone marrow and other organ microenvironment in contact with osteolytic (Walker W256) and osteoblastic (MatLyLu MLL) metastases were investigated. Fisher and Copenhagen rats...

  • Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activation. Samant, Rajeev S.; Clark, David W.; Fillmore, Rebecca A.; Cicek, Muzaffer; Metge, Brandon J.; Chandramouli, Kondethimmana H.; Chambers, Ann F.; Casey, Graham; . Welch, Danny R; Lalita A Shevde // Molecular Cancer;2007, Vol. 6, p6 

    Background: Osteopontin (OPN), a secreted phosphoglycoprotein, has been strongly associated with tumor progression and aggressive cancers. MDA-MB-435 cells secrete very high levels of OPN. However metastasis-suppressed MDA-MB-435 cells, which were transfected with breast cancer metastasis...

  • Transcriptional Repression of Catalase in Mouse Skin Tumor Progression. Kwei, Kevin A.; Finch, Joanne S.; Thompson, Eric J.; Bowden, G. Tim // Neoplasia;Sep/Oct2004, Vol. 6 Issue 5, p440 

    Previous studies in our laboratory have shown that the elevation of reactive oxygen species levels and the repression of the antioxidant enzyme, catalase, played a critical role in the in vitro progression of benign papilloma cells to malignant carcinoma cells. Catalase message, protein levels,...

  • Senescence: Improved detection. Seton-Rogers, Sarah // Nature Reviews Cancer;Mar2013, Vol. 13 Issue 3, p150 

    The article discusses a study conducted by researcher Norman Sharpless and colleagues who have developed a knock-in mouse which expresses luciferase at the locus encoding the senescence promoter and tumour suppressor INK4A or p16INK4A which seems to act as a factor of early tumorigenesis. It is...

  • Monitoring of cerebral perfusion pressure during intracranial hypertension: a sufficient parameter of adequate cerebral perfusion and oxygenation? Thees, Christof; Scheufler, Kai-Michael; Nadstawek, Joachim; Zentner, Josef; Lehnert, Ariane; Hoeft, Andreas // Intensive Care Medicine;Mar2003, Vol. 29 Issue 3, p386 

    Objective: A cerebral perfusion pressure (CPP) oriented treatment is a widely accepted standard for patients with intracranial hypertension. In an animal model of controlled intracranial hypertension we investigated whether CPP is a reliable parameter of sufficient cerebral...

  • Inhalation of 7.5% carbon dioxide increases alerting and orienting attention network function. Garner, Matthew; Attwood, Angela; Baldwin, David; Munafò, Marcus // Psychopharmacology;Sep2012, Vol. 223 Issue 1, p67 

    Rationale: The development of experimental models that readily translate between animals and humans is required to better integrate and clarify the biological, behavioural and cognitive mechanisms that underlie normal fear and pathological anxiety. Inhalation of low concentrations of carbon...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics