TITLE

Air pollution, obesity, genes and cellular adhesion molecules

AUTHOR(S)
Madrigano, Jaime; Baccarelli, Andrea; Wright, Robert O.; Suh, Helen; Sparrow, David; Vokonas, Pantal S.; Schwartz, Joel
PUB. DATE
May 2010
SOURCE
Occupational & Environmental Medicine;May2010, Vol. 67 Issue 5, p6
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives Particulate matter has been associated with acute cardiovascular outcomes, but our understanding of the mechanism is incomplete. We examined the association between particulate matter and cell adhesion molecules. We also investigated the modifying effect of genotype and phenotype variation to gain insight into the relevant biological pathways for this association. Methods We used mixed regression models to examine the association of PM2.5 (particulate matter ≤2.5 α/4m in diameter) and black carbon with serum concentrations of soluble intercellular adhesion molecule (sICAM-1) and soluble vascular cell adhesion molecule (sVCAM-1), markers of endothelial function and inflammation, in a longitudinal study of 809 participants in the Normative Ageing Study (1819 total observations). We also examined whether this association was modified by genotype, obesity or diabetes status. Genes selected for analyses were either related to oxidative stress, endothelial function, lipid metabolism or metal processing. Results Black carbon during the 2 days prior to blood draw was significantly associated with increased sVCAM-1 (4.5% increase per 1 α/4g/m3, 95% CI 1.1 to 8.0). Neither pollutant was associated with sICAM-1. Larger effects of black carbon on sVCAM were seen in subjects with obesity (p=0.007) and who were GSTM1 null (p=0.02). Conclusions Black carbon is associated with markers of endothelial function and inflammation. Genes related to oxidative defence may modify this association.
ACCESSION #
51698596

 

Related Articles

  • Soluble inter-cellular adhesion molecule-1 in urban Asian north Indians: Relationships with anthropometric and metabolic covariates. Sethi, Astha; Misra, Anoop; Pandey, Ravindra Mohan; Luthra, Kalpana; Devi, J. Rama; Sharma, Rekha; Khanna, Nidhi; Dwivedi, Manjari; Vikram, Naval Kishore // Disease Markers;2002, Vol. 18 Issue 3, p111 

    Background: High prevalence of diabetes, obesity, and dyslipidemias in people belonging to poor socio-economic strata in urban slums of northern India has been recorded recently. To assess whether this population has high levels of soluble intercellular adhesion molecule-1 (sICAM-1), a cytokine...

  • Switching α-Glucosidase Inhibitors to Miglitol Reduced Glucose Fluctuations and Circulating Cardiovascular Disease Risk Factors in Type 2 Diabetic Japanese Patients. Hariya, Natsuyo; Mochizuki, Kazuki; Inoue, Seiya; Saito, Miyoko; Fuchigami, Masahiro; Goda, Toshinao; Osonoi, Takeshi // Drugs in R&D;Sep2014, Vol. 14 Issue 3, p177 

    Background and Objectives: In this study we examined the effects of switching α-glucosidase inhibitors (α-GI) from acarbose or voglibose to miglitol on glucose fluctuations and circulating concentrations of cardiovascular disease risk factors, such as soluble adhesion molecules...

  • Visfatin-induced expression of inflammatory mediators in human endothelial cells through the NF-κB pathway. Lee, W-J.; Wu, C-S.; Lin, H.; Lee, I-T.; Wu, C-M.; Tseng, J-J.; Chou, M-M.; Sheu, W. H-H. // International Journal of Obesity;Apr2009, Vol. 33 Issue 4, p465 

    Background:Visfatin is an adipokine that is highly expressed in visceral fat. Plasma levels of visfatin have been reported to be higher in subjects with obesity and/or type 2 diabetes mellitus. However, the role of visfatin in endothelial dysfunction has been largely unexplored.Objectives:We...

  • PARTICULATE MATTER AND DISEASE. Ghio, Andrew J. // BMJ: British Medical Journal (Overseas & Retired Doctors Edition;11/19/2011, Vol. 343 Issue 7832, p1047 

    A letter to the editor is presented regarding the relation between biomas burning and incidence of tuberculosis.

  • A novel biopsy method to increase yield of subcutaneous abdominal adipose tissue. Alderete, T L; Sattler, F R; Sheng, X; Tucci, J; Mittelman, S D; Grant, E G; Goran, M I // International Journal of Obesity;Jan2015, Vol. 39 Issue 1, p183 

    Collection of abdominal subcutaneous adipose tissue (SAT) for research testing is traditionally performed using punch biopsy or needle aspiration techniques, yielding small amounts of very superficial SAT (100-500 mg). Although liposuction techniques can be used to obtain large amounts of SAT,...

  • Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity. Pak, V M; Keenan, B T; Jackson, N; Grandner, M A; Maislin, G; Teff, K; Schwab, R J; Arnardottir, E S; Júlíusson, S; Benediktsdottir, B; Gislason, T; Pack, A I // International Journal of Obesity;Mar2015, Vol. 39 Issue 3, p472 

    Background:Elevated levels of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) may contribute to cardiovascular disease and are associated with obstructive sleep apnea (OSA) and obesity. The relationship between OSA and obesity in determining ICAM-1 and...

  • Air Pollution Increases CVD Risk in Women With Diabetes. Schaffer, Regina // O&P Business News;Jan2016, Vol. 25 Issue 1, p32 

    The article discusses research on air pollution and cardiovascular disease (CVD) in women with diabetes. It references a study led by Jaime E. Hart and published in the "Journal of the American Heart Association" that demonstrates high risks of CVD among women with diabetes and long-term...

  • Perfil alimentario de una población rural de Michoacán y su asociación con obesidad, diabetes e hipertensión. Muñoz-Ibarra, Adriana Ivett; Carranza-Madrigal, Jaime // Medicina Interna de Mexico;ene/feb2010, Vol. 26 Issue 1, p24 

    Background: In Mexico the nutritional imbalances for excess due to the acquisition of feeding inadequate habits constitute a risk for the development of obesity and other cardiovascular risk factors. Objective: To determine the vascular and metabolic characteristics and the dietary patterns in a...

  • Lifetime Risk of Cardiovascular Disease Among Individuals With and Without Diabetes Stratified by Obesity Status in the Framingham Heart Study. Fox, Caroline S.; Pencina, Michael J.; Wilson, Peter W. F.; Paynter, Nina P.; Vasan, Ramachandran S.; D'Agostino, Ralph B. // Diabetes Care;Aug2008, Vol. 31 Issue 8, p1582 

    OBJECTIVE -- We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes. RESEARCH DESIGN AND METHODS -- Participants were drawn from the original and offspring cohorts of the Framingham Heart Study. Lifetime (30-year) risk of CVD was...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics