Hyperhomocysteinemia, Low Folate, and Vitamin B12Deficiency in Elderly Living at Home and Care Residences: A Comparative Study

Gharaibeh, Mohammad Y.
July 2010
Laboratory Medicine;Jul2010, Vol. 41 Issue 7, p410
Academic Journal
BACKGROUND: Serum levels of homocysteine (Hcy), folate, and vitamin B12in healthy elderly persons living at home (EH) and care residences (ER) were evaluated in subjects from Jordan. METHODS: Homocysteine, folate, and vitamin B12serum levels were measured using commercially available kits. RESULTS: The prevalence of hyperhomocysteinemia (HHcy) was 55% in the ER, 22% in the EH, and 8% in the young. Vitamin B12deficiency was prevalent in 34% of the elderly groups compared to 9% in the young group. Similarly, the folate deficiency prevalence was 55% and 23% in the ER and EH respectively, whereas it was 13% in the young group. Homocysteine concentration negatively correlated with vitamin B12in EH males and females, while it negatively correlated with folate in the EH and the young of both genders. CONCLUSION: Hyperhomocysteinemia and low folate was more prevalent in the ER than in the EH and younger individuals.


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