Soy and the exercise-induced inflammatory response in postmenopausal women

Beavers, Kristen M.; Serra, Monica C.; Beavers, Daniel P.; Cooke, Matthew B.; Willoughby, Darryn S.
June 2010
Applied Physiology, Nutrition & Metabolism;Jun2010, Vol. 35 Issue 3, p261
Academic Journal
Aging is associated with increasing inflammation and oxidative stress in the body, both of which can have negative health effects. Successful attenuation of such processes with dietary countermeasures has major public health implications. Soy foods, as a source of high-quality protein and isoflavones, may improve such indices, although the effects in healthy postmenopausal women are not well delineated. A single-blind, randomized controlled trial was conducted in 31 postmenopausal women who were assigned to consume 3 servings of soy (n = 16) or dairy (n = 15) milk per day for 4 weeks. Parameters of systemic inflammation (tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6)) and the oxidative defense system (superoxide dismutase (SOD), glutathione peroxidase, cyclooxygenase-2) were measured post supplementation, before and after an eccentric exercise bout performed to elicit an inflammatory response. A significant group-by-time effect for plasma TNF-α was observed (p = 0.02), with values in the dairy group increased post supplementation and then decreasing into the postexercise period. Additionally, significant time effects were observed for plasma SOD (p < 0.0001) and IL-6 (p < 0.0001) in the postexercise period. Overall results from our study do not support the notion that 4 weeks of daily soy milk ingestion can attenuate systemic elevations in markers of inflammation or oxidative defense. However, data do suggest that the downhill-running protocol utilized in this study can be effective in altering systemic markers of inflammation and oxidative defense enzyme activity, and that the ingestion of soy may help prevent fluctuations in plasma TNF-α. Le vieillissement est associé à plus d’inflammation et de stress oxydatif dans l’organisme, ce qui entraine des effets négatifs sur la santé. L’atténuation de ces effets au moyen de mesures alimentaires s’avère de la plus haute importance en matière de santé publique. Les produits de soja, sources de protéines de grande qualité et d’isoflavones, recèlent un potentiel d’amélioration de ces processus; cependant on ne connait pas bien les effets chez les femmes postménopausées en bonne santé. Dans un essai clinique comparatif à simple insu et d’une durée de quatre semaines, on répartit au hasard 31 femmes postménopausées; 16 acceptent de consommer tous les jours trois portions de produits de soja et 15, des produits laitiers. Les paramètres de l’inflammation systémique (TNF-α, IL-1β, IL-6) et du système de défense contre l’oxydation (SOD, GPx, COX-2) sont évalués après la supplémentation, et ce, avant et après une séance d’exercices pliométriques suscitant une réponse inflammatoire. On observe un effet significatif du traitement en fonction du temps : les valeurs de TNF-α plasmatique (p = 0,02) du groupe consommant des produits laitiers augmentent après la supplémentation puis diminuent après la séance d’exercices. De plus, on observe un effet significatif en fonction du temps au sujet du SOD (p < 0,0001) et des IL-6 (p < 0,0001) plasmatiques après la séance d’exercices. D’après ces observations, la consommation quotidienne de boisson de soja durant quatre semaines n’atténue pas les augmentations des marqueurs de l’inflammation et du système de défense antioxydative. En contrepartie, ces observations suggèrent que la course sur pente négative utilisée dans cette étude est efficace dans la modification des marqueurs systémiques de l’inflammation et de l’activité enzymatique suscitée pour la défense antioxydative et que la consommation de soja peut contribuer à la prévention des fluctuations plasmatiques de TNF-α.


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