The effects of 4 weeks of an arginine-based supplement on the gas exchange threshold and peak oxygen uptake

Camic, Clayton L.; Housh, Terry J.; Mielke, Michelle; Zuniga, Jorge M.; Hendrix, C. Russell; Johnson, Glen O.; Schmidt, Richard J.; Housh, Dona J.
June 2010
Applied Physiology, Nutrition & Metabolism;Jun2010, Vol. 35 Issue 3, p286
Academic Journal
The purpose of the present study was to examine the effects of the daily administration of an arginine-based supplement for 4 weeks on the gas exchange threshold (GET) and peak oxygen uptake. The study used a double-blind, placebo-controlled design. Forty-one college-aged males (mean age ± SD = 22.1 ± 2.4 years) were randomized into either the PLACEBO (n = 20) or ARGININE (n = 21) group. The placebo was microcrystalline cellulose. The ARGININE group ingested 3.0 g of arginine, 300 mg of grape seed extract, and 300 mg of polyethylene glycol. All subjects performed an incremental test to exhaustion on a cycle ergometer prior to supplementation (PRE) and after 4 weeks of supplementation (POST). The GET was determined by using the V-slope method of the carbon dioxide output vs. oxygen uptake relationship. The results indicated that there were significant mean increases (PRE to POST) in GET (4.1%), as well as in carbon dioxide output (4.3%) and power output (5.4%) at the GET for the ARGININE group, but no significant changes for the PLACEBO group (2.5%, 4.3%, and 3.9%, respectively). In addition, there were no significant changes in peak oxygen uptake for the ARGININE (-1.0%) or PLACEBO (-1.5%) groups. These findings supported the use of the arginine-based supplement for increasing GET and the associated power output, but not for increasing peak oxygen uptake during cycle ergometry. Cette étude se propose d’analyser les effets de l’administration quotidienne d’un supplément à base d’arginine durant quatre semaines sur le seuil des échanges gazeux (GET) et la consommation d’oxygène de pointe. On se sert d’un devis expérimental à double insu et d’un groupe de contrôle. Quarante-et-un hommes âgés de 22,1 ± 2,4 ans (moyenne ± écart-type) sont répartis aléatoirement dans 2 groupes, PLACEBO (n = 20) ou ARGININE (n = 21). La substance placebo est de la cellulose microcristalline. Le groupe expérimental consomme 3,0 g d’arginine, 300 mg d’extrait de pépin de raisin et 300 mg de glycol polyéthylénique. Avant la supplémentation (PRE) et quatre semaines après cette dernière (POST), tous les sujets participent à une épreuve d’effort progressif jusqu’à épuisement sur une bicyclette ergométrique. On détermine le GET par la méthode du point d’intersection sur la pente production de gaz carbonique contre la consommation d’oxygène de pointe. De PRE à POST, on observe dans le groupe expérimental une augmentation significative du GET (4,1 %), du production de gaz carbonique (4,3 %) et de la puissance produite (5,4 %) au GET; on n’observe aucune variation significative dans le groupe de contrôle (2,5 %, 4,3 % et 3,9 %, respectivement). En outre, on n’observe aucune augmentation significative du consommation d’oxygène de pointe dans le groupe expérimental (-1,0 %) et le groupe de contrôle (-1,5 %). D’après ces observations, on peut consommer un supplément à base d’arginine pour élever le GET et la puissance produite au GET, mais pas pour augmenter la consommation d’oxygène de pointe sur une bicyclette ergométrique.


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