TITLE

Activity of chequerboard combinations of ceftaroline and NXL104 versus β-lactamase-producing Enterobacteriaceae

AUTHOR(S)
Mushtaq, S.; Warner, M.; Williams, G.; Critchley, I.; Livermore, D. M.
PUB. DATE
July 2010
SOURCE
Journal of Antimicrobial Chemotherapy (JAC);Jul2010, Vol. 65 Issue 7, p1428
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Ceftaroline is a novel oxyimino-cephalosporin, strongly active against methicillin-resistant staphylococci and pneumococci. It is active against Enterobacteriaceae too, but is labile to common β-lactamases, including AmpC and extended-spectrum types. To counteract these enzymes, ceftaroline is also being developed combined with NXL104, a β-lactamase inhibitor.
ACCESSION #
51493361

 

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