Activity of chequerboard combinations of ceftaroline and NXL104 versus β-lactamase-producing Enterobacteriaceae

Mushtaq, S.; Warner, M.; Williams, G.; Critchley, I.; Livermore, D. M.
July 2010
Journal of Antimicrobial Chemotherapy (JAC);Jul2010, Vol. 65 Issue 7, p1428
Academic Journal
Background: Ceftaroline is a novel oxyimino-cephalosporin, strongly active against methicillin-resistant staphylococci and pneumococci. It is active against Enterobacteriaceae too, but is labile to common β-lactamases, including AmpC and extended-spectrum types. To counteract these enzymes, ceftaroline is also being developed combined with NXL104, a β-lactamase inhibitor.


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