The distinctive profile of risk factors of nasopharyngeal carcinoma in comparison with other head and neck cancer types

Abdulamir, A. S.; Hafidh, R. R.; Abdulmuhaimen, N.; Abubakar, F.; Abbas, K. A.
January 2008
BMC Public Health;2008, Vol. 8 Issue 1, p400
Academic Journal
Background: Nasopharyngeal carcinoma (NPC) and other head and neck cancer (HNCA) types show a great epidemiological variation in different regions of the world. NPC has multifactorial etiology and many interacting risk factors are involved in NPC development mainly Epstein Barr virus (EBV). There is a need to scrutinize the complicated network of risk factors affecting NPC and how far they are different from that of other HNCA types. Methods: 122 HNCA patients and 100 control subjects were studied in the region of the Middle East. Three types of HNCA were involved in our study, NPC, carcinoma of larynx (CL), and hypopharyngeal carcinoma (HPC). The risk factors studied were the level of EBV serum IgG and IgA antibodies measured by ELISA, age, sex, smoking, alcohol intake, histology, and family history of the disease. Results: EBV serum level of IgG and IgA antibodies was higher in NPC than CL, HPC, and control groups (p < 0.01). NPC was associated with lymphoepithelioma (LE) tumors, males, regular alcohol intake, and regular smoking while CL and HPC were not (p < 0.05). CL and HPC were associated with SCC tumors (p < 0.05). Furthermore, NPC, unlike CL and HPC groups, was not affected by the positive family history of HNCA (p > 0.05). The serum levels of EBV IgG and IgA antibodies were higher in LE tumors, regular smokers, younger patients, and negative family history groups of NPC patients than SCC tumors, non-regular smokers, older patients and positive family history groups respectively (p < 0.05) while this was not found in the regular alcoholics (p > 0.05). Conclusion: It was concluded that risk factors of NPC deviate much from that of other HNCA. EBV, smoking, alcohol intake, LE tumors, male patient, and age > 54 years were hot risk factors of NPC while SCC and positive family history of the disease were not. Earlier incidence, smoking, LE tumors, and negative family history of the disease in NPC patients were associated much clearly with EBV. It is proposed that determining the correct risk factors of NPC is vital in assigning the correct risk groups of NPC which helps the early detection and screening of NPC.


Related Articles

  • Second primary esophageal or lung cancer in patients with head and neck carcinoma in Taiwan: incidence and risk in relation to primary index tumor site. Chen, Min-Chi; Chen, Ping-Tsung; Chan, Chunghuang; Yang, Cheng-Ta; Chen, Chih-Cheng; Huang, Cih-En; Lu, Chang-Hsien; Lee, Kuan-Der // Journal of Cancer Research & Clinical Oncology;Jan2011, Vol. 137 Issue 1, p115 

    Background: Second primary cancer is prevalent in patients with head and neck cancer (HNC), for which esophagus and lung are the most usual sites, associated with an extremely poor prognosis. However, information regarding the actual risk of second primary esophageal or lung cancer in South-east...

  • The effect of CYP1A1, GSTT1 and GSTM1 polymorphisms on the risk of lung cancer: A case—control study. Atinkaya, Cansel; Taspinar, Mehmet; Sakiragaoglu, Onur; Oz, Gurhan; Yazici, Ulku; Oztuna, Derya; Tastepe, Irfan; Sunguroglu, Asuman // Human & Experimental Toxicology;Oct2012, Vol. 31 Issue 10, p1074 

    Lung cancer, which is mainly affected by environmental factors, is a lethal malignancy. It is also important to investigate the effect of genetic factors on lung cancer aetiology. In this study, we aimed to investigate the distribution of CYP1A1*2C, GSTT1 and GSTM1 polymorphisms in Turkish lung...

  • Prostate Cancer in Older Men. Calabrese, Dorothy A. // Urologic Nursing;Aug2004, Vol. 24 Issue 4, p258 

    Provides an overview of prostate cancer, treatment options and side effects in older men. Risk factors and etiology of prostate cancer; Signs and symptoms of prostate cancer; Diagnosis of prostate cancer; Screening for prostate cancer in older men.

  • Patterns of Risk of Cancer in Patients with Metal-on-Metal Hip Replacements versus Other Bearing Surface Types: A Record Linkage Study between a Prospective Joint Registry and General Practice Electronic Health Records in England. Lalmohamed, Arief; MacGregor, Alexander J.; de Vries, Frank; Leufkens, Hubertus G. M.; van Staa, Tjeerd P. // PLoS ONE;Jul2013, Vol. 8 Issue 7, p1 

    Background: There are concerns that metal-on-metal hip implants may cause cancer. The objective of this study was to evaluate patterns and timing of risk of cancer in patients with metal-on-metal total hip replacements (THR). Methods: In a linkage study between the English National Joint...

  • ROLE OF SMOKING IN CERVICAL ONCOGENESIS. GÎNFĂLEAN, GEORGETA // Acta Medica Transilvanica;mar2015, Vol. 20 Issue 1, p12 

    The knowledge of cervical cancer and its etiology has registered a remarkable development. Recent studies have highlighted the link between smoking and cervical cancer, this not being dependent of sexual behaviour. Smoking is, therefore, considered a risk factor in the incidence of cervical...

  • Housework Reduces All-Cause and Cancer Mortality in Chinese Men Yu, Ruby; Leung, Jason; Woo, Jean // PLoS ONE;May2013, Vol. 8 Issue 5, p1 

    Background: Leisure time physical activity has been extensively studied. However, the health benefits of non-leisure time physical activity, particular those undertaken at home on all-cause and cancer mortality are limited, particularly among the elderly. Methods: We studied physical...

  • Pathway Analysis for Genome-Wide Association Study of Lung Cancer in Han Chinese Population. Zhang, Ruyang; Zhao, Yang; Chu, Minjie; Wu, Chen; Jin, Guangfu; Dai, Juncheng; Wang, Cheng; Hu, Lingmin; Gou, Jianwei; Qian, Chen; Bai, Jianling; Wu, Tangchun; Hu, Zhibin; Lin, Dongxin; Shen, Hongbing; Chen, Feng // PLoS ONE;Mar2013, Vol. 8 Issue 3, p1 

    Genome-wide association studies (GWAS) have identified a number of genetic variants associated with lung cancer risk. However, these loci explain only a small fraction of lung cancer hereditability and other variants with weak effect may be lost in the GWAS approach due to the stringent...

  • Promoter hypermethylation of tumour suppressor genes in tumour cells from patients with head and neck cancer. Ščėsnaitė, Asta; Gudlevičienė, Živilė; Jarmalaitė, Sonata // Biologija;2008, Issue 3, p161 

    Head and neck cancer is a group of malignancies of the upper respiratory tract, its main risk factors being attributed to tobacco and alcohol consumption and human papillomavirus (HPV) infection. Promoter hypermethylation is one of the major mechanisms in the transcriptional inactivation of...

  • Ways that women may possibly reduce their risk of breast cancer. Brinton, Louise A. // JNCI: Journal of the National Cancer Institute;9/21/94, Vol. 86 Issue 18, p1371 

    Editorial. Comments on several studies which focused on identifying the risk factors of breast cancer. Dietary means of lowering risk; Benefits of high levels of physical exercise; Re-emergence of breast feeding; Possible adverse impact of oral contraceptives and oral estrogen; Role of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics