The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult men

Menke, Andy; Guallar, Eliseo; Shiels, Meredith S.; Rohrmann, Sabine; Basaria, Shehzad; Rifai, Nader; Nelson, William G.; Platz, Elizabeth A.
January 2008
BMC Public Health;2008, Vol. 8 Issue 1, p72
Academic Journal
Background: Studies investigating the association of cadmium and sex steroid hormones in men have been inconsistent, but previous studies were relatively small. Methods: In a nationally representative sample of 1,262 men participating in the morning examination session of phase I (1998-1991) of the third National Health and Nutrition Examination Survey, creatinine corrected urinary cadmium and serum concentrations of sex steroid hormones were measured following a standardized protocol. Results: After adjustment for age and race-ethnicity, higher cadmium levels were associated with higher levels of total testosterone, total estradiol, sex hormone-binding globulin, estimated free testosterone, and estimated free estradiol (each p-trend < 0.05). After additionally adjusting for smoking status and serum cotinine, none of the hormones maintained an association with urinary cadmium (each p-trend > 0.05). Conclusion: Urinary cadmium levels were not associated with sex steroid hormone concentrations in a large nationally representative sample of US men.


Related Articles

  • Estradiol Concentration Levels and Cognitive Impairment. Walling, Anne D. // American Family Physician;2/1/2001, Vol. 63 Issue 3, p544 

    Presents a study by K. Yaffe and others that studied the association between serum concentration levels of estradiol (non-protein-bound and bioavailable) and testosterone concentration levels (total and non-protein-bound) and the risk of cognitive impairment in elderly women. Description of the...

  • Soy Product Intake and Serum Isoflavonoid and Estradiol Concentrations in Relation to Bone Mineral Density in Postmenopausal Japanese Women. Nagata, C.; Shimizu, H.; Takami, R.; Hayashi, M.; Takeda, N.; Yasuda, K. // Osteoporosis International;Mar2002, Vol. 13 Issue 3, p200 

    : To evaluate soy intake and serum concentrations of estradiol and isoflavonoids and their relationship to bone mineral density (BMD) and serum bone-specific alkaline phosphatase (bone ALP) activity, we conducted a cross-sectional study of 87 postmenopausal Japanese women. Soy product and...

  • Antimicrobial peptidomimetics: reinterpreting nature to deliver innovative therapeutics. Scorciapino, Mariano A.; Rinaldi, Andrea C.; Robinson, Mark W. // Frontiers in Immunology;Jun2012, Vol. 3, p1 

    A review of the article "Role of female sex hormones, estradiol and progesterone, in mast cell behavior," by Oliver Zierau, Ana C. Zenclussen, and Federico Jensen, which appeared in the periodical "Frontiers in Immunology" on June 19, 2012, is presented.

  • Estrogenic Response in Male Bullfrog ( Rana catesbeiana) Hepatocytes After Single or Combined Exposure to Cadmium (Cd) and 17beta-Estradiol (E2). Lee, Keun; Chang, Ziwei; Oh, Beom-Seok; Lu, Ming; Park, Jang-Su // Bulletin of Environmental Contamination & Toxicology;Nov2010, Vol. 85 Issue 5, p452 

    Contamination by heavy metals and sex hormones in a water environment is an important health issue. In this study, we investigated the estrogenic effects of cadmium (Cd) administration alone and in combination with 17beta-estradiol (E2) on the hepatocytes of male Bullfrog ( Rana catesbeiana)....

  • Sexual dimorphism of cadmium-induced toxicity in rats: involvement of sex hormones. Shimada, Hideaki; Hashiguchi, Takashi; Yasutake, Akira; Waalkes, Michael; Imamura, Yorishige // Archives of Toxicology;Sep2012, Vol. 86 Issue 9, p1475 

    The toxic effect of cadmium varies with sex in experimental animals. Previous studies have demonstrated that pretreatment of male Fischer 344 (F344) rats with the female sex hormone progesterone markedly enhances the susceptibility to cadmium, suggesting a role for progesterone in the sexual...

  • Effect of Soybean (Glycine max L.) on the Hormonal Milieu of Male Rats. Ekaluo, U. B.; Udoh, P. B.; Ikpeme, E. V.; Udensi, O. // Pakistan Journal of Biological Sciences;7/15/2011, Vol. 14 Issue 14, p752 

    Effect of soybean (Glycine max) on serum level of some sex hormones: testosterone, follicle stimulating hormone (FSH), luteinizing hormone/interstitial cell stimulating hormone (LH/ICSH), estradiol and prolactin in male rats was investigated. Twenty male albino rats of 12 weeks old with similar...

  • EFFECT OF INHALATION EXPOSURE TO GASOLINE ON SEX HORMONES PROFILE IN WISTAR ALBINO RATS. Uboh, F. E.; Akpanabiatu, M. I.; Ekaidem, I. S.; Ebong, P. E.; Umoh, I. B. // Acta Endocrinologica (1841-0987);Jan-Mar2007, Vol. 3 Issue 1, p23 

    12 adult male and 12 female Wistar albino rats were used to measure the levels of the serum follicle stimulating hormone (FSH), the luteinizing hormone (LH), the estradiol (E2) and the progesterone in female rats, as well as the FSH, the LH and the testosterone in male rats, following 8-hour...

  • Effects of Hydro-alcoholic Extract of Red Dried Stigmas of Crocus sativus L. Flowers (saffron) on the Levels of Pituitary-ovary Hormones and Folliculogenesis in Rats. Mokhtari, Mokhtar; Sharifi, Esfandiar; Daneshi, Adel // International Journal of Fertility & Sterility;Feb/Mar2010, Vol. 3 Issue 4, p185 

    Background: In the present study the effects of a hydro-alcoholic saffron (Crocus sativus) extract on pituitary-ovary axis and folliculogenesis were investigated. The aim was to study the possible role of saffron in female fertility and thereby, show its usefulness in treating infertility and...

  • Increased admission serum estradiol level is correlated with high mortality in patients with severe acute pancreatitis. Lu, Chih-Wei; Liu, Liang-Chih; Hsieh, Ya-Ching; Yang, Li-Heng; Chen, Ray-Jade; Hsieh, Chi-Hsun // Journal of Gastroenterology;Mar2013, Vol. 48 Issue 3, p374 

    Background: Sexual dimorphism in critical diseases has been documented. Severe acute pancreatitis is a disease with high mortality. We hypothesized that admission sex hormone levels may be used as an early predictor of outcome in these patients. Methods: A prospective cohort of patients with...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics