TITLE

A systematic review of delay in the diagnosis and treatment of tuberculosis

AUTHOR(S)
Storla, Dag Gundersen; Yimer, Solomon; Bjune, Gunnar Aksel
PUB. DATE
January 2008
SOURCE
BMC Public Health;2008, Vol. 8, p15
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Early diagnosis and immediate initiation of treatment are essential for an effective tuberculosis (TB) control program. Delay in diagnosis is significant to both disease prognosis at the individual level and transmission within the community. Most transmissions occur between the onset of cough and initiation of treatment. Methods: A systematic review of 58 studies addressing delay in diagnosis and treatment of TB was performed. We found different definitions of, for example, debut of symptoms, first appropriate health care provider, time to diagnosis, and start of treatment. Rather than excluding studies that failed to meet strict scientific criteria (like in a meta-analysis), we tried to extract the "solid findings" from all of them to arrive on a more global understanding of diagnostic delay in TB. Results: The main factors associated with diagnostic delay included human immunodeficiency virus; coexistence of chronic cough and/or other lung diseases; negative sputum smear; extrapulmonary TB; rural residence; low access (geographical or sociopsychological barriers); initial visitation of a government low-level healthcare facility, private practitioner, or traditional healer; old age; poverty; female sex; alcoholism and substance abuse; history of immigration; low educational level; low awareness of TB; incomprehensive beliefs; self-treatment; and stigma. Conclusion: The core problem in delay of diagnosis and treatment seemed to be a vicious cycle of repeated visits at the same healthcare level, resulting in nonspecific antibiotic treatment and failure to access specialized TB services. Once generation of a specific diagnosis was in reach, TB treatment was initiated within a reasonable period of time.
ACCESSION #
51487545

 

Related Articles

  • Barriers to Completing TB Diagnosis in Yemen: Services Should Respond to Patients' Needs. Anderson de Cuevas, Rachel M.; Al-Sonboli, Najla; Al-Aghbari, Nasher; Yassin, Mohammed A.; Cuevas, Luis E.; Theobald, Sally J. // PLoS ONE;Sep2014, Vol. 9 Issue 9, p1 

    Objectives and Background: Obtaining a diagnosis of tuberculosis (TB) is a prerequisite for accessing specific treatment, yet one third of estimated new cases are missed worldwide by National Programmes. This study investigated economic, geographical, socio-cultural and health system factors...

  • Erythrocyte sedimentation rate at diagnosis in culture positive cases of active tuberculosis. Yousuf, Muhammad; Salih, Salih Bin; Al-Johani, Sameera; Alothman, Adel // Pakistan Journal of Medical Sciences;Jan2012, Vol. 28 Issue 1, p87 

    Objective: To evluate the Erythocyte Sedimentation Rate (ESR) at the time of diagnosis in culture positive cases of different types of active tuberculosis (TB). Methodology: In this retrospective descriptive study conducted at King Abdulaziz Medical City, Riyadh, Saudi Arabia, ESR was done by a...

  • HIV-Associated Tuberculosis: Clinical Update. Swaminathan, Soumya; Padmapriyadarsini, C.; Narendran, G. // Clinical Infectious Diseases;5/15/2010, Vol. 50 Issue 10, p1377 

    The human immunodeficiency virus (HIV) epidemic has led to an increase in the incidence of tuberculosis globally, particularly in sub-Saharan Africa. Coinfection with HIV leads to difficulties in both the diagnosis and treatment of tuberculosis. Because of the poor performance of sputum smear...

  • Diagnosis and management of miliary tuberculosis: current state and future perspectives. Ray, Sayantan; Talukdar, Arunansu; Kundu, Supratip; Khanra, Dibbendhu; Sonthalia, Nikhil // Therapeutics & Clinical Risk Management;2013, Vol. 9, p9 

    Tuberculosis (TB) remains one of the most important causes of death from an infectious disease, and it poses formidable challenges to global health at the public health, scientific, and political level. Miliary TB is a potentially fatal form of TB that results from massive lymphohematogenous...

  • Hopelessness as a basis for tuberculosis diagnostic delay in the Arkhangelsk region: a grounded theory study. Kuznetsov, Vladimir N.; Grjibovski, Andrej M.; Mariandyshev, Andrej O.; Johansson, Eva; Enarson, Donald A.; Bjune, Gunnar A. // BMC Public Health;2013, Vol. 13 Issue 1, p1 

    Background: Data about delayed tuberculosis diagnosis in Northern Russia are scarce yet such knowledge could enhance the care of tuberculosis. The Arkhangelsk region is situated in the north of Russia, where the population is more than one million residents. The aim of the study was to...

  • Supplement 2: Diagnosis and treatment of latent TB infection and active TB.  // MMWR: Morbidity & Mortality Weekly Report;10/28/94 Supplement RR-13, Vol. 43 Issue 42, p59 

    Discusses the diagnosis and treatment of latent and active TB infection. Diagnostic procedures for TB infection and disease; Preventive therapy for latent TB infection and treatment of active TB.

  • A puzzling tumour. Kamara, Achmed; Dubrey, Simon; Osman, Majdi; Mikel, John; Phillips, Gerrard // Thorax;Dec2012, Vol. 67 Issue 12, p1116 

    A quiz concerning the investigation and management of possible tuberculosis is presented.

  • The Quality of Tuberculosis Services in Health Care Centres in a Rural District in Uganda: The Providers' and Clients' Perspective. Bulage, Lilian; Sekandi, Juliet; Kigenyi, Omar; Mupere, Ezekiel // Tuberculosis Research & Treatment;2014, p1 

    Quality of care plays an important role in the status of tuberculosis (TB) control, by influencing timely diagnosis, treatment adherence, and treatment completion. In this study, we aimed at establishing the quality of TB service care in Kamuli district health care centres using Donabedian...

  • EVALUATION OF ISONIAZID PREVENTIVE THERAPY POLICY. Modi, Bhavesh; Dave, Paresh // National Journal of Community Medicine;Jan-Mar2012, Vol. 3 Issue 1, p171 

    The article presents information on a study which evaluates exiting isoniazid preventive therapy (IPT) policy of the U.S. It depicts logistic difficulties in performing tuberculin skin tests to diagnose latent tuberculosis (TB) infection. It suggests that National human immunodeficiency virus...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics