Cardiovascular disease in a cohort exposed to the 1940-45 Channel Islands occupation

Head, Rosemary F.; Gilthorpe, Mark S.; Byrom, Allyson; Ellison, George T. H.
January 2008
BMC Public Health;2008, Vol. 8 Issue 1, p303
Academic Journal
Background: To clarify the nature of the relationship between food deprivation/undernutrition during pre- and postnatal development and cardiovascular disease (CVD) in later life, this study examined the relationship between birth weight (as a marker of prenatal nutrition) and the incidence of hospital admissions for CVD from 1997-2005 amongst 873 Guernsey islanders (born in 1923-1937), 225 of whom had been exposed to food deprivation as children, adolescents or young adults (i.e. postnatal undernutrition) during the 1940-45 German occupation of the Channel Islands, and 648 of whom had left or been evacuated from the islands before the occupation began. Methods: Three sets of Cox regression models were used to investigate (A) the relationship between birth weight and CVD, (B) the relationship between postnatal exposure to the occupation and CVD and (C) any interaction between birth weight, postnatal exposure to the occupation and CVD. These models also tested for any interactions between birth weight and sex, and postnatal exposure to the occupation and parish of residence at birth (as a marker of parish residence during the occupation and related variation in the severity of food deprivation). Results: The first set of models (A) found no relationship between birth weight and CVD even after adjustment for potential confounders (hazard ratio (HR) per kg increase in birth weight: 1.12; 95% confidence intervals (CI): 0.70 - 1.78), and there was no significant interaction between birth weight and sex (p = 0.60). The second set of models (B) found a significant relationship between postnatal exposure to the occupation and CVD after adjustment for potential confounders (HR for exposed vs. unexposed group: 2.52; 95% CI: 1.54 - 4.13), as well as a significant interaction between postnatal exposure to the occupation and parish of residence at birth (p = 0.01), such that those born in urban parishes (where food deprivation was worst) had a greater HR for CVD than those born in rural parishes. The third model (C) found no interaction between birth weight and exposure to the occupation (p = 0.43). Conclusion: These findings suggest that the levels of postnatal undernutrition experienced by children, adolescents and young adults exposed to food deprivation during the 1940-45 occupation of the Channel Islands were a more important determinant of CVD in later life than the levels of prenatal undernutrition experienced in utero prior to the occupation.


Related Articles

  • Physical Activity Following Pregnancy in Women at Risk for Cardiovascular Disease. Davenport, Margie H.; Steinback, Craig D. // Research Update;Jul2014, Vol. 21 Issue 3, p1 

    This article highlights recent findings from a study examining the impact of postpartum exercise in women at risk for the future development of cardiovascular disease. The authors suggest that a 12-week, moderate-intensity exercise program is an effective intervention to reduce cardiovascular...

  • Adolescent smoking: Behavioural risk factors and health beliefs. Umeh, Kanayo; Griffiths, Mark // Education & Health;2001, Vol. 19 Issue 4, p69 

    Deals with a study which assessed the role of cognitive factors of smoking behavior in several teenagers. Health promotion initiatives to reduced risk for cardiovascular disease; Number of deaths due to cardiovascular disease in Great Britain each year; Assessment of perceived benefits and...

  • FAMILIES, YOUNG PEOPLE AND HEALTH CARE. Reed, Michael; Wraith, Caroline // Family Matters;Winter96 Australian, Issue 44, p30 

    This article discusses the importance of the promotion of family health, the strengthening of links between young people, their families and the community, and the development of integrative services and policies. In promoting an alliance between families, young people and health care, this...

  • Overfeeding During Early Postnatal Period Causes Permanent Reprogramming of Brown Adipose Tissue Adaptive Thermogenesis. Xiao, Xiao Q.; Williams, Sarah M.; Grayson, Bernadette E.; Glavas, Maria M.; Smith, M. Susan; Grove, Kevin L. // Diabetes;Jun2007 Supplement 1, Vol. 56, pA355 

    Overnutrition during early postnatal period in the rodent impacts the subsequent risk for metabolic and cardiovascular diseases. The current study investigates the effect of chronic postnata overfeeding (CPO) on body weight regulation and its relation to brown adipose tissue (BAT) thermogenesis....

  • Diet and Exercise Interventions among Overweight and Obese Lactating Women: Randomized Trial of Effects on Cardiovascular Risk Factors. Brekke, Hilde K.; Bertz, Fredrik; Rasmussen, Kathleen M.; Bosaeus, Ingvar; EllegĂ„rd, Lars; Winkvist, Anna // PLoS ONE;Feb2014, Vol. 9 Issue 2, p1 

    Objective: To examine the effects of Diet (D) and Exercise (E) interventions on cardiovascular fitness, waist circumference, blood lipids, glucose metabolism, inflammation markers, insulin-like growth factor 1 (IGF-1) and blood pressure in overweight and obese lactating women. Methods: At...

  • Muscular fitness and clustered cardiovascular disease risk in Australian youth. Magnussen, Costan; Schmidt, Michael; Dwyer, Terence; Venn, Alison // European Journal of Applied Physiology;Aug2012, Vol. 112 Issue 8, p3167 

    Low cardiorespiratory fitness (CRF) is a risk factor for cardiovascular disease (CVD) but the association of muscular fitness phenotypes (strength, endurance and power) on CVD risk in youth has not been examined. We examined the cross-sectional association between muscular fitness phenotypes...

  • Prevalence of cardiovascular risk factors among Hamedeni adolescents. Khodaveisi, M.; Yaghobi, A.; Borzou, R. // Journal of School of Public Health & Institute of Public Health ;2011, Vol. 8 Issue 4, p31 

    Background and Aim: Cardiovascular diseases are the main cause of death in the world. Several factors such as lifestyle can alter incidence of these diseases. Cardiovascular diseases originate from childhood; therefore, early prevention must begin from childhood and adolescence in order to be...

  • Prediction and prevention of sudden death in young populations: the role of ECG screening. Dougherty, Kevin; Friedman, Richard; Link, Mark; Estes, N. // Journal of Interventional Cardiac Electrophysiology;Mar2013, Vol. 36 Issue 2, p167 

    Sudden cardiac death (SCD), particularly when it affects a child or a young athlete who is presumed to be healthy, is an emotionally charged event that has a widespread impact. An effective ECG screening strategy for this population is intuitively appealing. The primary objective of ECG...

  • High blood sugar, obesity, poor diet, smoking, little exercise make adolescents unhealthiest in US history.  // Biomedical Market Newsletter;11/21/2011, Vol. 21, p572 

    The article reports on the issue regarding the cardiovascular health of adolescents in the U.S. According to a Northwestern Medicine research, teenagers are more likely to die of heart disease at a younger age, compared to adults. It notes that there has been an increase in cardiovascular...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics