TITLE

Study protocol--metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: a randomised, placebo-controlled, double-blind vitamin D intervention

AUTHOR(S)
von Hurst, Pamela R.; Stonehouse, Welma; Matthys, Christophe; Conlon, Cathryn; Kruger, Marlena C.; Coad, Jane
PUB. DATE
January 2008
SOURCE
BMC Public Health;2008, Vol. 8 Issue 1, p267
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The identification of the vitamin D receptor in the endocrine pancreas suggests a role for vitamin D in insulin secretion. There is also some limited evidence that vitamin D influences insulin resistance, and thus the early stages of the development of type 2 diabetes. Methods: Eighty-four women of South Asian origin, living in Auckland, New Zealand, were randomised to receive either a supplement (4000IU 25(OH)D3 per day) or a placebo for 6 months. At baseline, all participants were vitamin D deficient (serum 25(OH)D3 <50 nmol/L), insulin resistant (HOMA-IR > 1.93) and/or hyperinsulinaemic, hyperglycemic or had clinical signs of dislipidaemia. Changes in HOMA-IR, lipids, parathyroid hormone, calcium and bone markers were monitored at 3 months and 6 months. Discussion: This randomised, controlled trial will be the first to investigate the effect of vitamin D supplementation on insulin resistance in non-diabetic subjects. It will subsequently contribute to the growing body of evidence about the role of vitamin D in metabolic syndrome. Registered clinical. Trial registration: Registered clinical trial - Registration No. ACTRN12607000642482
ACCESSION #
51486042

 

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