Pulmonary tuberculosis among people living with HIV/AIDS attending care and treatment in rural northern Tanzania

Ngowi, Bernard J.; Mfinanga, Sayoki G.; Bruun, Johan N.; Morkve, Odd
January 2008
BMC Public Health;2008, Vol. 8, p341
Academic Journal
Background: Tuberculosis is the commonest opportunistic infection and the number one cause of death in HIV/AIDS patients in developing countries. To address the extent of the tuberculosis HIV coinfection in rural Tanzania we conducted a cross sectional study including HIV/AIDS patients attending care and treatment clinic from September 2006 to March 2007. Methods: Sputum samples were collected for microscopy, culture and drug susceptibility testing. Chest X-ray was done for those patients who consented. Blood samples were collected for CD4+ T cells count. Results: The prevalence of tuberculosis was 20/233 (8.5%). Twenty (8.5%) sputum samples were culture positive. Eight of the culture positive samples (40%) were smear positive. Fifteen (75%) of these patients neither had clinical symptoms nor chest X-ray findings suggestive of tuberculosis. Nineteen isolates (95%) were susceptible to rifampicin, isoniazid, streptomycin and ethambutol (the first line tuberculosis drugs). One isolate (5%) from HIV/tuberculosis coinfected patients was resistant to isoniazid. No cases of multi- drug resistant tuberculosis were identified. Conclusion: We found high prevalence of tuberculosis disease in this setting. Chest radiograph suggestive of tuberculosis and clinical symptoms of fever and cough were uncommon findings in HIV/tuberculosis coinfected patients. Tuberculosis can occur at any stage of CD4+T cells depletion.


Related Articles

  • Pneumocystis Pneumonia in HIV-positive Adults, Malawi. Van Oosterhout, Joep J. G.; Laufer, Miriam K.; Perez, M. Arantza; Graham, Stephen M.; Chimbiya, Nelson; Thesing, Phillip C.; Álvarez-Martinez, Miriam J.; Wilson, Paul E.; Chagomerana, Maganizo; Zijlstra, Eduard E.; Taylor, Terrie E.; Plowe, Christopher V.; Meshnick, Steven R. // Emerging Infectious Diseases;Feb2007, Vol. 13 Issue 2, p325 

    In a prospective study of 660 HIV-positive Malawian adults, we diagnosed Pneumocystis jirovecii pneumonia (PcP) using clinical features, induced sputum for immunofluorescent staining, real-time PCR, and posttreatment follow-up. PcP incidence was highest in patients with the lowest CD4 counts,...

  • Bleach-digested sputum smears for the diagnosis of TB in HIV-infected individuals. Douthwaite, S.; Yassin, M. A.; Squire, S. B.; Arbide, I.; Cuevas, L. E. // Tropical Doctor;Jan2007, Vol. 37 Issue 1, p35 

    We describe the performance of bleach-digested Zeihl-Neelsen (ZN) smears in TB suspects with/without HIV. In total, 51 (26%) and 62 (31%) out of the first 198 spot and digested smears were positive. Seven of the 30 HIV-positive patients had TB and their ZN smears were negative, scanty or 1 +....

  • Multiple Tuberculous Brain Abscesses in an HIV-Infected Patient Successfully Treated with HAART and Antituberculous Treatment. Bottieau, E.; Noë, A.; Florence, E.; Colebunders, R. // Infection; 

    Tuberculous brain abscesses (TBA) are an unusual clinical presentation of central nervous system tuberculosis occurring extremely infrequently in developed countries, and almost always in immunocompromised patients. Before the introduction of highly active antiretroviral therapy (HAART), TBA...

  • Spread of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal Province, South Africa. Moodley, Prashini; Shah, N. Sarita; Tayob, Nabihah; Connolly, Cathy; Zetola, Nicola; Gandhi, Neel; Friedland, Gerald; Sturm, A. Willem // PLoS ONE;2011, Vol. 6 Issue 5, p1 

    Background: In 2005 a cluster of 53 HIV-infected patients with extensively drug-resistant tuberculosis (XDR-TB) was detected in the Msinga sub-district, the catchment area for the Church of Scotland Hospital (CoSH) in Tugela Ferry, in KwaZulu-Natal province (KZN), South Africa. KZN is divided...

  • The Impact of HIV on the Usefulness of Sputum Smears for the Diagnosis of Tuberculosis. Long, Richard; Scalcini, Marcella; Manfreda, Jure; Jean-Baptiste, Michel; Herchfield, Earl // American Journal of Public Health;Oct91, Vol. 81 Issue 10, p1326 

    In a developing country, 289 patients were examined for active pulmonary mycobacterial disease (sputum smear and culture) and HIV infection (serology) to compare the sensitivity and positive predictive value of sputum smears for diagnosing pulmonary tuberculosis in patients with and without...

  • Detection of Tuberculosis in HIV-Infected and -Uninfected African Adults Using Whole Blood RNA Expression Signatures: A Case-Control Study. Kaforou, Myrsini; Wright, Victoria J.; Oni, Tolu; French, Neil; Anderson, Suzanne T.; Bangani, Nonzwakazi; Banwell, Claire M.; Brent, Andrew J.; Crampin, Amelia C.; Dockrell, Hazel M.; Eley, Brian; Heyderman, Robert S.; Hibberd, Martin L.; Kern, Florian; Langford, Paul R.; Ling, Ling; Mendelson, Marc; Ottenhoff, Tom H.; Zgambo, Femia; Wilkinson, Robert J. // PLoS Medicine;Oct2013, Vol. 10 Issue 10, p1 

    : Using a microarray-based approach, Michael Levin and colleagues develop a disease risk score to distinguish active from latent tuberculosis, as well as tuberculosis from other diseases, using whole blood samples. Please see later in the article for the Editors' Summary

  • Nucleic Acid Amplification Tests for Diagnosis of Smear- Negative TB in a High HIV-Prevalence Setting: A Prospective Cohort Study. Davis, J. Lucian; Huang, Laurence; Worodria, William; Masur, Henry; Cattamanchi, Adithya; Huber, Charles; Miller, Cecily; Conville, Patricia S.; Murray, Patrick; Kovacs, Joseph A. // PLoS ONE;2011, Vol. 6 Issue 1, p1 

    Background: Nucleic acid amplification tests are sensitive for identifying Mycobacterium tuberculosis in populations with positive sputum smears for acid-fast bacilli, but less sensitive in sputum-smear-negative populations. Few studies have evaluated the clinical impact of these tests in...

  • The Diagnostic Performance of a Single GeneXpert MTB/RIF Assay in an Intensified Tuberculosis Case Finding Survey among HIV-Infected Prisoners in Malaysia. Al-Darraji, Haider Abdulrazzaq Abed; Razak, Humaira Abd; Ng, Kee Peng; Altice, Frederick L.; Kamarulzaman, Adeeba // PLoS ONE;Sep2013, Vol. 8 Issue 9, p1 

    Background:Delays in tuberculosis (TB) diagnosis, particularly in prisons, is associated with detrimental outcomes. The new GeneXpert MTB/RIF assay (Xpert) offers accurate and rapid diagnosis of active TB, but its performance in improving case detection in high-transmission congregate settings...

  • A RARE CASE OF PULMONARY NOCARDIASIS IN AN AIDS PATIENT. Sreedevi Reddy, S.; Madhusudhan Reddy, K.; Saraswathi, K. // Indian Journal of Medical Sciences;Apr2010, Vol. 64 Issue 4, p192 

    Nocardia infections are rare among normal individuals. Mostly they occur in immunocompromised individuals. Here, we report a case of pulmonary nocardiosis in a person who was diagnosed as having pulmonary tuberculosis and was treated with antituberculous treatment for 6 months. But the sputum...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics