Alcohol use as a risk factor for tuberculosis - a systematic review

Lönnroth, Knut; Williams, Brian G.; Stadlin, Stephanie; Jaramillo, Ernesto; Dye, Christopher
January 2008
BMC Public Health;2008, Vol. 8 Issue 1, p289
Academic Journal
Background: It has long been evident that there is an association between alcohol use and risk of tuberculosis. It has not been established to what extent this association is confounded by social and other factors related to alcohol use. Nor has the strength of the association been established. The objective of this study was to systematically review the available evidence on the association between alcohol use and the risk of tuberculosis. Methods: Based on a systematic literature review, we identified 3 cohort and 18 case control studies. These were further categorized according to definition of exposure, type of tuberculosis used as study outcome, and confounders controlled for. Pooled effect sizes were obtained for each sub-category of studies. Results: The pooled relative risk across all studies that used an exposure cut-off level set at 40 g alcohol per day or above, or defined exposure as a clinical diagnosis of an alcohol use disorder, was 3.50 (95% CI: 2.01-5.93). After exclusion of small studies, because of suspected publication bias, the pooled relative risk was 2.94 (95% CI: 1.89-4.59). Subgroup analyses of studies that had controlled for various sets of confounders did not give significantly different results and did not explain the significant heterogeneity that was found across the studies. Conclusion: The risk of active tuberculosis is substantially elevated in people who drink more than 40 g alcohol per day, and/or have an alcohol use disorder. This may be due to both increased risk of infection related to specific social mixing patterns associated with alcohol use, as well as influence on the immune system of alcohol itself and of alcohol related conditions.


Related Articles

  • Infectious diseases.  // MLO: Medical Laboratory Observer;Feb2010, Vol. 42 Issue 2, p8 

    The article presents information on the U.S. first case of extremely drug-resistant tuberculosis (XXDR-TB) found in a Peruvian student living in Florida.

  • Identification and Management of Tuberculosis. Jerant, Anthony F.; Bannon, Michelle; Rittenhouse, Stephen // American Family Physician;5/1/2000, Vol. 61 Issue 9, p2667 

    Discusses about the identification and management of tuberculosis. Screening for tuberculosis; Treatment of latent tuberculosis infection; Prevention of nosocomial transmission.

  • Serologic Methods for Diagnosing Tuberculosis. Good, Robert C. // Annals of Internal Medicine;1/15/89, Vol. 110 Issue 2, p97 

    Editorial. Discusses the serologic methods for diagnosing tuberculosis. Reason for the increase in cases of pulmonary tuberculosis in the U.S. in 1986; Causative agents of tuberculosis; Problems presented by serologic tests that use monoclonal antibodies for antigen detection.

  • Performance of QuantiFERON-TB testing in a tuberculosis outbreak at a primary school.  // Current Medical Literature: Respiratory Medicine;2008, Vol. 22 Issue 3, p76 

    The article discusses research being done on the performance of QuantiFERON-TB (QFT) testing in a tuberculosis (TB) outbreak at a primary school in Italy. It references a study by P. Molicotti et al which appeared in a 2008 issue of the "Journal of Pediatrics." Results showed that QFT test was...

  • Epidemiology and Clinical Features of Pulmonary Nontuberculous Mycobacteriosis in Nagasaki, Japan. Ide, Shotaro; Nakamura, Shigeki; Yamamoto, Yoshihiro; Kohno, Yoshihisa; Fukuda, Yuichi; Ikeda, Hideki; Sasaki, Eisuke; Yanagihara, Katsunori; Higashiyama, Yasuhito; Hashiguchi, Kohji; Futsuki, Yoji; Inoue, Yuichi; Fukushima, Kiyoyasu; Suyama, Naofumi; Kohno, Shigeru // PLoS ONE;May2015, Vol. 10 Issue 5, p1 

    Background and Objectives: Recent reports indicate that the incidence of nontuberculous mycobacterial-lung disease (NTM-LD) is increasing. This study aimed to investigate the epidemiology and clinical features of NTM-LD patients in Nagasaki prefecture, Japan to identify the negative prognostic...

  • Blood assays outperform skin test in TB diagnosis. Foster, Melissa; Lawrence, Leah; Raible, Eric; Volansky, Rob // Infectious Disease News;Jun2010, Vol. 23 Issue 6, p25 

    The article discusses research on the use of Quantiferon-TB Gold In-Tube Assay and T-Spot.TB assay to diagnose tuberculosis (TB), by R. Diel and colleagues, published in the 2010 issue of "Chest."

  • Tuberculosis.  // Thorax;Dec2003 Supplement 3, Vol. 58, piii55 

    Rifampicin resistance can be rapidly diagnosed in over 95% of cases by amplifying an 8lbp region of the rpoB gene. Of new R resistant Mtb isolates in Great Britain, 85-90% are also resistant to isoniazid (MDRTB). The prompt recognition of MDRTB and the early diagnosis of multiply resistant...

  • Infecção por Mycobacterium tuberculosis entre agentes comunitários de saúde que atuam no controle da TB. Rodrigues, Patrícia Marques; Moreira, Tiago Ricardo; De Moraes, Andressa Karla Luz; Vieira, Rafael da Cruz Araújo; Dietze, Reynaldo; Lima, Rita de Cassia Duarte; Maciel, Ethel Leonor Noia // Jornal Brasileiro de Pneumologia;apr2009, Vol. 35 Issue 4, p351 

    Objective: To evaluate the incidence of Mycobacterium tuberculosis infection, using tuberculin skin test, among community health agents (CHAs) monitoring TB patients in the city of Cachoeiro de Itapemirim, Brazil. Methods: We included 30 CHAs acting in the Family Health Program and 30 of their...

  • CHAPTER 16: Tuberculosis. Thuraisingham, Helen // Fundamental Aspects of Nursing Adults with Respiratory Disorders;2007, p189 

    Chapter 16 of the book "Fundamental Aspects of Nursing Adults With Respiratory Disorders" is presented. It provides an overview of the respiratory disease called tuberculosis. It highlights the management of patients inflicted with tuberculosis, including diagnosis, treatment and the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics