High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose Study

Hadaegh, Farzad; Bozorgmanesh, Mohammad Reza; Ghasemi, Asghar; Harati, Hadi; Saadat, Navid; Azizi, Fereidoun
January 2008
BMC Public Health;2008, Vol. 8 Issue 1, p176
Academic Journal
Background: To estimate the prevalence of diagnosed and undiagnosed diabetes mellitus, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and combined IFG/IGT in a large urban Iranian population aged ⩾ 20 years. Methods: The study population included 9,489 participants of the Tehran Lipid and Glucose Study with full relevant clinical data. Age-standardized prevalence of diabetes and glucose intolerance categories were reported according to the 2003 American Diabetes Association definitions. Age-adjusted logistic regression models were used to estimate the numbers needed to screen (NNTS) to find one person with undiagnosed diabetes. Results: The prevalence of diagnosed and undiagnosed diabetes, isolated IFG, isolated IGT, and combined IFG/IGT were 8.1%, 5.1%, 8.7%, 5.4% and 4.0% in men and 10%, 4.7%, 6.3%, 7.6%, and 4.5% in women respectively. Participants with undiagnosed diabetes had higher age, body mass index (BMI), waist circumference, systolic and diastolic blood pressures, triglycerides (all p values <0.001) and lower HDL-cholesterol (only in women, p < 0.01) compared to normoglycemic subjects. Undiagnosed diabetes was associated with family history of diabetes, increased BMI (⩾ 25 kg/m²), abdominal obesity, hypertriglyceridemia, hypertension and low HDL-cholesterol levels. Among men, a combination of increased BMI, hypertension, and family history of diabetes led to a NNTS of 1.6 (95% CI: 1.57-1.71) and among women a combination of family history of diabetes and abdominal obesity, yielded a NNTS of 2.2 (95% CI: 2.1-2.4). Conclusion: In conclusion, about one third of Tehranian adults had disturbed glucose tolerance or diabetes. One-third of total cases with diabetes were undiagnosed. Screening individuals with BMI ⩾ 25 kg/m² (men), hypertension (men), abdominal obesity (women) and family history of diabetes may be more efficient.


Related Articles

  • Effects of a pharmaceutical care model on medication adherence and glycemic control of people with type 2 diabetes. Wen Wei Chung; Siew Siang Chua; Siew Mei Lai, Pauline; Siew Pheng Chan // Patient Preference & Adherence;2014, Vol. 8, p1185 

    Background: Diabetes mellitus is a lifelong chronic condition that requires self-management. Lifestyle modification and adherence to antidiabetes medications are the major determinants of therapeutic success in the management of diabetes. Purpose: To assess the effects of a pharmaceutical care...

  • Long-term effect of metformin on blood glucose control in non-obese patients with type 2 diabetes mellitus. Ito, Hiroyuki; Ishida, Hidenori; Takeuchi, Yuichiro; Antoku, Shinichi; Abe, Mariko; Mifune, Mizuo; Togane, Michiko // Nutrition & Metabolism;2010, Vol. 7, p83 

    Background: We aimed to investigate the long-term effect of metformin on the blood glucose control in non-obese patients with type 2 diabetes mellitus. Methods: A retrospective study was performed in 213 patients with type 2 diabetes mellitus under the administration of metformin for more than...

  • Gene Variants Associated with Transient Neonatal Diabetes Mellitus in the Very Low Birth Weight Infant. anderson de la Llana, Sabrina; Klee, Philippe; Santoni, Federico; Stekelenburg, Caroline; Blouin, Jean-Louis; Schwitzgebel, Valerie M. // Hormone Research in Paediatrics;Nov2015, Vol. 84 Issue 4, p283 

    Background: Transient and permanent neonatal diabetes mellitus (NDM), usually defined as diabetes diagnosed within the first 6 months of life, are rare conditions occurring in 1:90,000-260,000 live births. The origin of NDM is rarely related to type 1 diabetes, but rather to single gene defects....

  • CLINICAL UTILITY OF CORONARY CALCIUM SCORING IN DIABETIC PATIENTS WITH NORMAL OR MILD ISCHEMIA IN MYOCARDIAL PERFUSION SCINTIGRAPHY. El-Guindy, Amr; Nassar, Ahmed; El-Rahman, Ahmed Abd; Aziz, Mohamed Abdel // International Journal of Academic Research;Nov2011, Vol. 3 Issue 6, p249 

    Background: Diabetic patients have a high prevalence of coronary atherosclerosis, once CAD is manifested clinically; diabetic patients continue to have a worse prognosis compared with non-diabetic patients both acutely after the event and during long-term follow-up. So detection of coronary...

  • Preliminary analysis of immune activation in early onset type 2 diabetes. Rempel, Julia D.; Packiasamy, Juliet; Dean, Heather J.; McGavock, Jonathon; Janke, Alyssa; Collister, Mark; Wicklow, Brandy; Sellers, Elizabeth A. C. // Circumpolar Health Supplements;2013 Supplement 1, Vol. 72, p293 

    Introduction. First Nations and other Aboriginal children are disproportionately affected by cardiometabolic diseases, including type 2 diabetes (T2D). In T2D, the disruption of insulin signalling can be driven by proinflammatory immunity. Pro-inflammatory responses can be fueled by toll-like...

  • Diabetes Type II, a new perspective. Oberleas, D. // Trace Elements & Electrolytes;2011 1st Quarter, Vol. 28 Issue 1, p52 

    Abstract. Evidence exists that chromium3+ is required as a cofactor for normal insulin function. People with Type II diabetes usually synthesize ample insulin but the insulin is not effectively utilized. Insulin must form a stable union with insulin receptors at least for brief periods in the...

  • Effects of basal insulin application on serum visfatin and adiponectin levels in type 2 diabetes. WEI-DONG WANG; LIN XING; JUN-RU TENG; SHUO LI; NA MI // Experimental & Therapeutic Medicine;2015, Vol. 9 Issue 6, p2219 

    The aim of this study was to investigate the effects of basal insulin application on the serum visfatin and adiponectin (APN) levels of patients with type 2 diabetes mellitus (T2DM). A total of 200 patients with T2DM, who were diagnosed in The Third People's Hospital of Jinan (glycosylated...

  • Benefits of tight glucose control queried.  // GP: General Practitioner;8/5/2011, p10 

    The article offers information on the research conducted, which revealed the benefits of tight glucose control. It states that the risks of pursuing intensive glucose control in type-2 diabetes may outweigh any benefits. It mentions that the researchers looked at trials involving 34,533 patients...

  • 30 Year Patterns of Mortality in Tobago, West Indies, 1976-2005: Impact of Glucose Intolerance and Alcohol Intake. Molokhia, Mariam; Nitsch, Dorothea; Patrick, Alan Leslie; McKeigue, Paul // PLoS ONE;2011, Vol. 6 Issue 1, p1 

    Objectives: To determine the main predictors of all-cause and cardiovascular (CV) mortality in a rural West Indian population in Plymouth, Tobago over 30 years. Methods: Questionnaire survey for CV risk factors and alcohol consumption patterns administered at baseline in 1976 with 92.5% response...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics