TITLE

HangOut: generating clean PSI-BLAST profiles for domains with long insertions

AUTHOR(S)
Kim, Bong-Hyun; Cong, Qian; Grishin, Nick V.
PUB. DATE
June 2010
SOURCE
Bioinformatics;Jun2010, Vol. 26 Issue 12, p1564
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Summary: Profile-based similarity search is an essential step in structure-function studies of proteins. However, inclusion of non-homologous sequence segments into a profile causes its corruption and results in false positives. Profile corruption is common in multidomain proteins, and single domains with long insertions are a significant source of errors. We developed a procedure (HangOut) that, for a single domain with specified insertion position, cleans erroneously extended PSI-BLAST alignments to generate better profiles.
ACCESSION #
51398550

 

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