TITLE

Managing Aromatase Inhibitors in Breast Cancer Survivors: Not Just for Oncologists

AUTHOR(S)
Files, Julia A.; Ko, Marcia G.; Pruthi, Sandhya
PUB. DATE
June 2010
SOURCE
Mayo Clinic Proceedings;Jun2010, Vol. 85 Issue 6, p560
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The role of the general internist in the care of breast cancer survivors is increasing as the number of women living with breast cancer continues to rise. Most breast cancers occurring in women older than 50 years are estrogen receptor- and/or progesterone receptor-positive, and adjuvant endocrine therapy plays an important role in the treatment plan. Aromatase inhibitors are becoming the preferred endocrine therapy, and general internists caring for breast cancer survivors need to be familiar with their use and adverse effect profile. This article reviews the use of aromatase inhibitors, the frequency of common adverse effects, and strategies for their management.
ACCESSION #
51302205

 

Related Articles

  • Relationship between estrogen receptor, progesterone receptor, HER-2 and Ki67 expression and efficacy of aromatase inhibitors in advanced breast cancer. Anderson, H.; Hills, M.; Zabaglo, L.; A'Hern, R.; Leary, A. F.; Haynes, B. P.; Smith, I. E.; Dowsett, M. // Annals of Oncology;Aug2011, Vol. 22 Issue 8, p1770 

    Background: Surprisingly few data are published on the relevance of even commonly used biomarkers of response to aromatase inhibitors (AIs) in advanced breast cancer. Here, we aim to determine the effectiveness of AIs in that setting according to quantitative levels of estrogen receptor (ER),...

  • Progesterone receptor modulators in breast cancer. WIEHLE, Ronald D. // Turkish Journal of Biology;2014, Vol. 38 Issue 6, p772 

    Breast cancer has been treated successfully with selective estrogen receptor antagonists (SERMs) such as tamoxifen, receptor-depleting agents such as fulvestrant, and aromatase inhibitors such as anastrozole. Selective progesterone receptor modulators (SPRMs or PRMs) have not been studied as...

  • Estrogen-dependent sushi domain containing 3 regulates cytoskeleton organization and migration in breast cancer cells. Moy, I; Todorović, V; Dubash, A D; Coon, J S; Parker, J B; Buranapramest, M; Huang, C C; Zhao, H; Green, K J; Bulun, S E // Oncogene;1/15/2015, Vol. 34 Issue 3, p323 

    Aromatase inhibitors (AIs) are the standard endocrine therapy for postmenopausal breast cancer; however, currently used biomarkers, such as, estrogen receptor-alpha/progesterone receptor (ERα/PR), predict only slightly more than half of the potential responders to AI treatment. To identify...

  • Aromatase inhibitors raise CV risk by 26%.  // Reactions Weekly;2/5/2011, Issue 1337, p1 

    The article focuses on a meta-analysis presented at the San Antonio Breast Cancer Symposium which showed that postmenopausal women with early breast cancer are more likely to develop heart disease when treated with an aromatase inhibitors than with tamoxifen.

  • Exemestane.  // Reactions Weekly;9/18/2010, Issue 1319, p24 

    The article describes the case of a 55-year-old woman who was suffering intraepithelial microcysts radiating from the limbus of both eyes after receiving exemestane 25 milligrams (mg) per day for breast cancer.

  • Fulvestrant for advanced male breast cancer patients: a case series. Masci, G.; Gandini, C.; Zuradelli, M.; Pedrazzoli, P.; Torrisi, R.; Lutman, F. R.; Santoro, A. // Annals of Oncology;Apr2011, Vol. 22 Issue 4, p985 

    No abstract available.

  • Osteoporosis and aromatase inhibitors: experience and future prospects. Bosco, Daniela // Clinical Cases in Mineral & Bone Metabolism;May-Aug2012, Vol. 9 Issue 2, p89 

    Introduction. The aim of this study is to improve the assistance given to patients under treatment with aromatase inhibitors in order to prevent secondary osteoporosis through the planning of an awareness programme for the oncologist and offering a facilitated treatment path. Materials and...

  • Molecular subtyping of DCIS: heterogeneity of breast cancer reflected in pre-invasive disease. Clark, S. E.; Warwick, J.; Carpenter, R.; Bowen, R. L.; Duffy, S. W.; Jones, J. L. // British Journal of Cancer;1/4/2011, Vol. 104 Issue 1, p120 

    Background:Molecular profiling has identified at least four subtypes of invasive breast carcinoma, which exhibit distinct clinical behaviour. There is good evidence now that DCIS represents the non-obligate precursor to invasive breast cancer and therefore it should be possible to identify...

  • Aromatase inhibitor anastrozole as a second-line hormonal treatment to a recurrent low-grade endometrial stromal sarcoma: a case report. Shoji, Keiko; Oda, Katsutoshi; Nakagawa, Shunsuke; Kawana, Kei; Yasugi, Toshiharu; Ikeda, Yuji; Takazawa, Yutaka; Kozuma, Shiro; Taketani, Yuji // Medical Oncology;Sep2011, Vol. 28 Issue 3, p771 

    Low-grade endometrial stromal sarcoma (ESS) is a rare neoplasm and is generally an indolent tumor with estrogen and progesterone receptors. Objective responses by hormonal treatment with progestin or aromatase inhibitor have been reported, however, long-term management of this disease could be...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics