Cholesteryl Ester Transfer Protein (CETP) Genotype and Reduced CETP Levels Associated With Decreased Prevalence of Hypertension

Schechter, Clyde B.; Barzilai, Nir; Crandall, Jill P.; Atzmon, Gil
June 2010
Mayo Clinic Proceedings;Jun2010, Vol. 85 Issue 6, p522
Academic Journal
OBJECTIVES: To clarify whether reduced cholesteryl ester transfer protein (CETP) activity carries inherent blood pressure risks and to infer whether the increased blood pressure and elevated mortality associated with torcetrapib are idiosyncratic or characteristic of this class of drugs. PATIENTS AND METHODS: We examined the associations among CETP genotype, phenotype, and blood pressure in a cohort of 521 older adults (who have complete data for the variables required in our primary analysis) enrolled between November 1, 1998, and June 30, 2003, in our ongoing studies of genes associated with longevity, including a cohort with a high prevalence of a genotype coding for a reduced activity variant of CETP and low levels of CETP. RESULTS: The prevalence of hypertension was actually lower among homozygotes for the variant CETP (48% vs 60% among those with wild-type and 65% among heterozygotes; P=.03). Low levels of CETP were associated with reduced prevalence of hypertension (65% in highest tertile, 59% in middle tertile, and 55% in lowest tertile; P=.04) and lower systolic blood pressure (140.8, 138.1, 136.2 mm Hg, respectively; P=.03). CONCLUSION: Reduced levels of CETP are associated with lower, not higher, blood pressure. The adverse results with torcetrapib, if mediated through blood pressure, are likely to represent effects of this specific drug, rather than a result of lower CETP levels.


Related Articles

  • Influence of the G-protein β-3 subunit gene C825 T polymorphism on the clinical phenotype of newly diagnosed essential hypertension. Jerrard-Dunne, P; Mahmud, A; Zhou, S; Feely, J // Journal of Human Hypertension;May2007, Vol. 21 Issue 5, p421 

    This study examined whether the G-protein polymorphism (GNB3-C825 T) predicts clinical phenotypes in untreated hypertensive subjects. GNB3 genotype had no influence on age at presentation, hypertension severity, arterial stiffness, microalbuminuria or renin-aldosterone axis activation. However,...

  • Apolipoprotein E polymorphism in Southern Iran: E4 allele in the lowest reported amounts. Masood Bazrgar; Mehran Karimi; Mohsen Fathzadeh; Sara Senemar; Farah Peiravian; Ashraf Shojaee; Mostafa Saadat // Molecular Biology Reports;Dec2008, Vol. 35 Issue 4, p495 

    Abstract   Background: Apolipoprotein E (apoE) with three major alleles E2, E3 and E4 is one of the critical genes in lipid metabolism. Common apoE alleles are in association with an increase in risk for central nervous and cardiovascular diseases such as Alzheimer’s disease,...

  • Microsatellite polymorphism of the human leptin gene (LEP) and risk of cardiovascular disease. Porreca, E.; Di Febbo, C.; Pintor, S.; Baccante, G.; Gatta, V.; Moretta, V.; Nisio, M. Di; Palka, C.; Cuccurullo, F.; Stuppia, L. // International Journal of Obesity;Feb2006, Vol. 30 Issue 2, p209 

    Background:No data have been so far reported on the relationship between polymorphisms of LEP gene and cardiovascular disease.Patients and methods:We genotyped a tetranucleotide repeat mapped in the 3′UTR of the LEP gene (LEP-tet) in 109 subjects with cardiovascular events and in 109...

  • SIRT1 Gene Polymorphisms Affect the Protein Expression in Cardiovascular Diseases. Kilic, Ulkan; Gok, Ozlem; Bacaksiz, Ahmet; Izmirli, Muzeyyen; Elibol-Can, Birsen; Uysal, Omer // PLoS ONE;Feb2014, Vol. 9 Issue 2, p1 

    Cardiovascular disease (CVD), the leading cause of death worldwide, is related to gene-environment interactions due to epigenetic factors. SIRT1 protein and its downstream pathways are critical for both normal homeostasis and protection from CVD-induced defects. The aim of this study was to...

  • Glutathione S-Transferase M1 (GSTM1) and T1 (GSTT1) Polymorphisms in a Brazilian Mixed Population. Hatagima, Ana; Marques, Christiane F.S.; Krieger, Henrique; Feitosa, Mary F. // Human Biology;Dec2004, Vol. 76 Issue 6, p937 

    The GSTM1 and GSTT1 null genotype frequencies were significantly different between 658 nonblack and black healthy blood donors from a Brazilian mixed population (Rio de Janeiro). The GSTM1 phenotype distribution was not in Hardy-Weinberg equilibrium in either group, mainly because of an excess...

  • Glutathione S-transferase M1 and T1 genotypes and myocardial infarction. Cora, Tulin; Tokac, Mehmet; Acar, Hasan; Soylu, Ahmet; Inan, Ziya // Molecular Biology Reports;Apr2013, Vol. 40 Issue 4, p3263 

    Myocardial infarction (MI), which is the most important manifestation of coronary artery disease, is the leading cause of morbidity and mortality in the world. Glutathione S transferases (GSTs) are enzymes responsible for the metabolism of numerous xenobiotics and are known to be polymorphic in...

  • Glutathione S-transferase A1, M1, P1 and T1 null or low-activity genotypes are associated with enhanced oxidative damage among haemodialysis patients. Suvakov, Sonja; Damjanovic, Tatjana; Stefanovic, Aleksandra; Pekmezovic, Tatjana; Savic-Radojevic, Ana; Pljesa-Ercegovac, Marija; Matic, Marija; Djukic, Tatjana; Coric, Vesna; Jakovljevic, Jovana; Ivanisevic, Jasmina; Pljesa, Steva; Jelic-Ivanovic, Zorana; Mimic-Oka, Jasmina; Dimkovic, Nada; Simic, Tatjana // Nephrology Dialysis Transplantation;Jan2013, Vol. 28 Issue 1, p202 

    Background Increased oxidative stress is a hallmark of end-stage renal disease (ESRD). Glutathione S-transferases (GST) are involved in the detoxification of xenobiotics and protection of oxidative damage. We hypothesized that genetic polymorphism in antioxidant enzymes GSTA1, GSTM1, GSTP1 and...

  • Glutathione S-Transferase â„£ 1 variation does not influence age at onset of Huntington's disease. Arning, Larissa; Jagiello, Peter; Wieczorek, Stefan; Saft, Carsten; Andrich, Jürgen; Epplen, Jörg T. // BMC Medical Genetics;2004, Vol. 5, p7 

    Background: Huntington's disease (HD) is a fully penetrant, autosomal dominantly inherited disorder associated with abnormal expansions of a stretch of perfect CAG repeats in the 5' part of the IT15 gene. The number of repeat units is highly predictive for the age at onset (AO) of the disorder....

  • Epistatic interactions in idiopathic pulmonary arterial hypertension. Vadapalli, Shivani; Satyanarayana, M. L.; Chaitra, K. L.; Rani, H. Surekh; Sastry, B. K. S.; Nallari, Pratibha // Indian Journal of Human Genetics;Jan-Apr2012, Vol. 18 Issue 1, p56 

    BACKGROUND: Idiopathic pulmonary arterial hypertension (IPAH) is a poorly understood complex disorder, which results in progressive remodeling of the pulmonary artery that ultimately leads to right ventricular failure. A two-hit hypothesis has been implicated in pathogenesis of IPAH, according...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics