Randomized Double-blind Comparison of Short-term Itraconazole and Terbinafine Therapy for Toenail Onychomycosis

DeGreef, Hugo; Del Palacio, Amalia; Mygind, Søren; Ginter, Gabriele; Pinto Soares, António; Zuluaga de Cadena, Angela
May 1999
Acta Dermato-Venereologica;5/27/99, Vol. 79 Issue 3, p221
Academic Journal
Previous studies evaluating short-term itraconazole and terbinafine therapy for onychomycosis have varied in protocol and size; this double-blind study enabled a large-scale, standardized, direct comparison. Patients with toenail onychomycosis were randomized to itraconazole 200 mg daily (n=146) or terbinafine 250 mg daily (n=146) for 12 weeks, with a 36-week follow-up. Mycological cure rates at the follow-up end-point were significantly equivalent (61% with itraconazole vs. 67% with terbinafine). A similar proportion of patients in each group experienced adverse events during treatment (itraconazole, 22%; terbinafine, 23%). More patients receiving terbinafine stopped treatment permanently because of treatment-related adverse events (8% vs. 1%).


Related Articles

  • Onychomycosis is more than a cosmetic concern. Park, Michael K. // Journal of Family Practice;Dec2007, Vol. 56 Issue 12, p984 

    A letter to the editor is presented in response to the article "Which oral antifungal is best for toenail onychomycosis?" in the 2007 issue.

  • Terbinafine Rates Best for Onychomycosis Cure. Guttman, Cheryl // Dermatology Times;Apr2000 Supplement 2, Vol. 21 Issue 4, pS7 

    Focuses on the effectiveness of the product, Terbinafine for treating toenail onychomycosis according to the presentation of physician E. Glyn V. Evans at the meeting of the American Academy of Dermatology. Study parameters measured in clinical trials; Advantages of the product over other...

  • Oral, Topical Combo Optimizes Therapy. Guttman, Cheryl // Dermatology Times;Apr2000 Supplement 2, Vol. 21 Issue 4, pS15 

    Focuses on the development of combined oral and topical antifungal drugs to treat onychomycosis according to the study findings of physician, James Q. del Rosso. Explanation of strategies to maximize treatment practices; Products recommended for combination therapy.

  • Randomized Double-blind Comparison of Short-term Itraconazole and Terbinafine Therapy for Toenail Onychomycosis. Safer, Leslie // Acta Dermato-Venereologica;09/20/2000, Vol. 80 Issue 4 

    Focuses on the use of itraconazole and terbinafine therapy for toenail onychomycosis. Decline of the mycological cure rates for itraconazole; Exclusion of the cases of hepatotoxicity in the terbinafine package insert; Treatment of dermatophytosis by an fungicidal agent terbinafine.

  • Onychomycosis: Making Sense of the Assessment of Anti-fungal Drugs: For debate. Shuster, Sam // Acta Dermato-Venereologica;4/20/98, Vol. 78 Issue 1, p1 

    After years of therapeutic triviality, we now have drugs with a major effect on onychomycosis, and, paradoxically, their very success will lead to the development of more such drugs. This note is concerned with improving their assessment by rationalising the way in which efficacy is measured....

  • Inverse Psoriasis Induced by Terbinafine. Pauluzzi, Paolo; Boccucci, Nicola // Acta Dermato-Venereologica;08/11/99, Vol. 79 Issue 5, p389 

    Presents the inverse psoriasis induced by terbinafine, a treatment for onychomycosis. Symptoms of the psoriatic disease; Adverse effects and cutaneous reactions of terbinafine; Importance of mycological investigation before commencing therapy for suspected onychomycosis.

  • Good News for Seniors. Hill, Suzette // Dermatology Times;Apr2003, Vol. 24 Issue 4, p26 

    Presents an approach to treating onychomycosis in older patients in Maui, Hawaii. Efficacy of combination drugs in improving the condition; Importance of drug compliance in ensuring the effectiveness of topical creams; Emphasis on promoting good foot hygiene to eliminate the causative agents.

  • Onychomycosis: First Case Due to Aspergillus nomius. Zotti, Mirca; Machetti, Marco; Persi, Agostino; Barabino, Gianfranco; Parodi, Aurora // Acta Dermato-Venereologica;2011, Vol. 91 Issue 5, p591 

    A letter to the editor is presented related to a case study on the diagnosis and treatment of onchomycosis which is caused by Aspergilllus nomius.

  • Oral Therapy for the Treatment of Onychomycosis. Kirchner, Jeffrey T. // American Family Physician;01/15/2001, Vol. 63 Issue 2, p345 

    Presents an abstract of the study `Onychomycosis: Improved Cure Rates With Itraconazole and Terbinafine,' by T.K. Harrell et al., from the July-August 2000 issue of the `Journal of the American Board of Family Practice.'


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics