TITLE

Randomized Double-blind Comparison of Short-term Itraconazole and Terbinafine Therapy for Toenail Onychomycosis

AUTHOR(S)
DeGreef, Hugo; Del Palacio, Amalia; Mygind, Søren; Ginter, Gabriele; Pinto Soares, António; Zuluaga de Cadena, Angela
PUB. DATE
May 1999
SOURCE
Acta Dermato-Venereologica;5/27/99, Vol. 79 Issue 3, p221
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Previous studies evaluating short-term itraconazole and terbinafine therapy for onychomycosis have varied in protocol and size; this double-blind study enabled a large-scale, standardized, direct comparison. Patients with toenail onychomycosis were randomized to itraconazole 200 mg daily (n=146) or terbinafine 250 mg daily (n=146) for 12 weeks, with a 36-week follow-up. Mycological cure rates at the follow-up end-point were significantly equivalent (61% with itraconazole vs. 67% with terbinafine). A similar proportion of patients in each group experienced adverse events during treatment (itraconazole, 22%; terbinafine, 23%). More patients receiving terbinafine stopped treatment permanently because of treatment-related adverse events (8% vs. 1%).
ACCESSION #
5122382

 

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