Thietanyl protection in the synthesis of 1-alkyl-8-bromo-3-methyl-3,7-dihydro-1 H-purine-2,6-diones

Khaliullin, F. A.; Shabalina, Yu. V.; Sharafutdinov, R. M.
May 2010
Russian Journal of Organic Chemistry;May2010, Vol. 46 Issue 5, p689
Academic Journal
The protection of the 7-NH group in 8-bromo-3-methyl-3,7-dihydro-1 H-pyrine-2,6-dione during the synthesis of 7-ubsubstituted 1-alkyl-8-bromo-3-methyl-3,7-dihydro-1 H-pyrine-2,6-diones with a thienyl group was applied that was introduced by the reaction with 2-chloromethylthiirane. The thietanyl protection was removed by treating with sodium alcoholate after the oxidation with hydrogen peroxide to thietane 1,1-dioxide group.


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