TITLE

Increasing fish consumption does not affect genotoxicity markers in the colon in an intervention study

AUTHOR(S)
Pot, Gerda K.; Habermann, Nina; Majsak-Newman, Gosia; Harvey, Linda J.; Geelen, Anouk; Przybylska-Philips, Kasia; Nagengast, Fokko M.; Witteman, Ben J. M.; van De Meeberg, Paul C.; Hart, Andrew R.; Schaafsma, Gertjan; Hooiveld, Guido; Glei, Michael; Lund, Elizabeth K.; Pool-Zobel, Beatrice L.; Kampman, Ellen
PUB. DATE
June 2010
SOURCE
Carcinogenesis;Jun2010, Vol. 31 Issue 6, p1087
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Observational studies suggest that fish consumption is associated with a decreased colorectal cancer (CRC) risk. A possible mechanism by which fish could reduce CRC risk is by decreasing colonic genotoxicity. However, concerns have also been raised over the levels of toxic compounds found in mainly oil-rich fish, which could increase genotoxicity. Therefore, the objective was to investigate the effects of fish on genotoxicity markers in the colon in a randomized controlled parallel intervention study. For a period of 6 months, subjects were randomly allocated to receive two extra weekly portions of (i) oil-rich fish (salmon), (ii) lean fish (cod) or (iii) just dietary advice (DA). The Comet Assay was used to measure the DNA damage-inducing potential of fecal water (n = 89) and DNA damage in colonocytes (n = 70) collected pre- and post-intervention as markers of genotoxicity. Genotoxicity of fecal water was not markedly changed after fish consumption: 1.0% increase in tail intensity (TI) [95% confidence interval (CI) −5.1; 7.0] in the salmon group and 0.4% increase in TI (95% CI −5.3; 6.1) in the cod group compared with the DA group. DNA damage in colonocytes was also not significantly changed after fish consumption, in either the salmon group (−0.5% TI, 95% CI −6.9; 6.0) or cod group (−3.3% TI, 95% CI −10.8; 4.3) compared with the DA group. Measurements of genotoxicity of fecal water and DNA damage in colonocytes did not correlate (r = 0.06, n = 34). In conclusion, increasing consumption of either oil-rich or lean fish did not affect genotoxicity markers in the colon.
ACCESSION #
51200360

 

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