HCV co-infection in HIV positive population in British Columbia, Canada

Buxton, Jane A.; Yu, Amanda; Kim, Paul H.; Spinelli, John J.; Kuo, Margot; Alvarez, Maria; Gilbert, Mark; Krajden, Mel
January 2010
BMC Public Health;2010, Vol. 10, p225
Academic Journal
Background: As HIV and hepatitis C (HCV) share some modes of transmission co-infection is not uncommon. This study used a population-based sample of HIV and HCV tested individuals to determine the prevalence of HIV/HCV coinfection, the sequence of virus diagnoses, and demographic and associated risk factors. Methods: Positive cases of HIV were linked to the combined laboratory database (of negative and positive HCV antibody results) and HCV reported cases in British Columbia (BC). Results: Of 4,598 HIV cases with personal identifiers, 3,219 (70%) were linked to the combined HCV database, 1,700 (53%) of these were anti-HCV positive. HCV was diagnosed first in 52% of co-infected cases (median time to HIV identification 3 ½ years). HIV and HCV was diagnosed within a two week window in 26% of cases. Among individuals who were diagnosed with HIV infection at baseline, subsequent diagnoses of HCV infection was independently associated with: i) intravenous drug use (IDU) in males and females, Hazard Ratio (HR) = 6.64 (95% CI: 4.86-9.07) and 9.76 (95% CI: 5.76-16.54) respectively; ii) reported Aboriginal ethnicity in females HR = 2.09 (95% CI: 1.34-3.27) and iii) males not identified as men-who-have-sex-with-men (MSM), HR = 2.99 (95% CI: 2.09-4.27). Identification of HCV first compared to HIV first was independently associated with IDU in males and females OR = 2.83 (95% CI: 1.84-4.37) and 2.25 (95% CI: 1.15-4.39) respectively, but not Aboriginal ethnicity or MSM. HIV was identified first in 22%, with median time to HCV identification of 15 months; Conclusion: The ability to link BC public health and laboratory HIV and HCV information provided a unique opportunity to explore demographic and risk factors associated with HIV/HCV co-infection. Over half of persons with HIV infection who were tested for HCV were anti-HCV positive; half of these had HCV diagnosed first with HIV identification a median 3.5 years later. This highlights the importance of public health follow-up and harm reduction measures for people identified with HCV to prevent subsequent HIV infection.


Related Articles

  • HIV gender-based vulnerabilities of women using drugs in long-term heterosexual relationships: baseline results from a randomized trial in Ukraine. Shulga, Liudmyla // Tobacco Control & Public Health in Eastern Europe;2012 Supplement 1, Vol. 2, ps55 

    BACKGROUND: Sexual way of HIV transmission in Ukraine outweighs parenteral route since 2007. In response to situation change couple's counseling for IDUs was introduced and is currently tested within randomized trial. METHODS: Baseline data were collected in June- September 2011: 548 IDU couples...

  • HCVHIV Coinfection: Simple Messages from a Complex Disease. Klenerman, Paul; Kim, Arthur // PLoS Medicine;Oct2007, Vol. 4 Issue 10, pe240 

    The authors discuss our current understanding of the immunopathogenesis of HCV-HIV coinfection.

  • Preventing HIV in prison.  // Australian Nursing Journal;Aug2003, Vol. 11 Issue 2, p22 

    Discusses research being done on the prevention of HIV and hepatitis C virus (HCV) transmission in prison. Reference to study by B.G. Sullivan and colleagues, published in the 2003 issue of the "Medical Journal of Australia"; Prevalence of HCV in prisons.

  • Bloodborne Pathogens. Twitchell, Katherine T.; Wachs, Joy E. // AAOHN Journal;Feb2003, Vol. 51 Issue 2, p89 

    Defines bloodborne pathogens in more detail and focuses on the general prevalence, risk groups, prophylaxis and treatment of hepatitis B, hepatitis C and HIV. Examples of bloodborne pathogens with the potential to cause disease in humans; History and epidemiology of hepatitis B; Information on...

  • Pharmacy Participation in Non-Prescription Syringe Sales in Los Angeles and San Francisco Counties, 2007. Cooper, Erin N.; Dodson, Chaka; Stopka, Thomas J.; Riley, Elise D.; Garfein, Richard S.; Bluthenthal, Ricky N. // Journal of Urban Health;Jul2010, Vol. 87 Issue 4, p543 

    Increasing sterile syringe access for injection drug users (IDUs) is one way to prevent HIV and hepatitis C virus (HCV) transmission in this population. In 2005, California Senate Bill 1159 allowed counties to adopt the Disease Prevention Demonstration Project (DPDP). Where enacted, the DPDP...

  • Reducing therapeutic injection overuse through patients-prescribers Interaction Group Discussions in Kinondoni District, Dar es Salaam, Tanzania. Massele, Amos Y.; Mashalla, Yohana J.; Kayombo, Edmund J.; Waiselage, Julius D.; Mwamba, Natu E.; Kaniki, Issessanda // Tanzania Journal of Health Research;Feb2011, Vol. 13 Issue 1, p87 

    Inappropriately prescription of injections has been reported in developing and developed countries. Previous studies in Tanzania showed that over 70% of patients attending out-patient clinics at private dispensaries received at least one injection per consultation, a value higher than WHO...

  • Incidence and estimated rates of residual risk for HIV, hepatitis C, hepatitis B and human T-cell lymphotropic viruses in blood donors in Canada, 1990--2000. Chiavetta, Jo Anne; Escobar, Michael; Newman, Alice; He, Yaohua; Driezen, Pete; Deeks, Shelley; Hone, Devon; O'Brien, Sheila; Sher, Graham // CMAJ: Canadian Medical Association Journal;10/14/2003, Vol. 169 Issue 8, p767 

    Background: Since 1990, the Canadian Red Cross Society and Canadian Blood Services have been testing blood donors for hepatitis C virus (HCV) antibody and HCV nucleic acids and have supplemented HIV antibody testing with p24 antigen testing. We report trends in the incidence of...

  • HIV And HCV Progression in Parenterally Coinfected Children. England, Kirsty; Thorne, Claire; Castelli-Gattinara, Guido; Vigano, Alessandra; Mehabresh, Mehadi I. El; Newell, Marie-Louise // Current HIV Research;May2009, Vol. 7 Issue 3, p346 

    Shared transmission routes of HCV and HIV mean parenteral HIV/HCV coinfection still occurs, often in resource-limited settings. The extent to which coinfection and treatment impact on morbidity and mortality in HIV/HCV coinfected children remains unknown thus optimal management and treatment is...

  • Concurrent infections of hepatitis C and HIV in hepatitis B patients in the north-east of Iran. Moradi, A.; Khodabakhshi, B.; Sadeghipour, M.; Besharat, S.; Tabarraei, A. // Tropical Doctor;Jul2011, Vol. 41 Issue 3, p129 

    Co-infection of HBV, HCV and HIV is common because of shared routes of viral transmission with increased risk of morbidity and mortality. Anti-HCV and HIV antibodies of 168 HBV patients were assayed. Co-infection of HCV in HBV patients was seen in four cases (2.4%). Simultaneous infection of HIV...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics