TITLE

Early incidence of occupational asthma among young bakers, pastry-makers and hairdressers: design of a retrospective cohort study

AUTHOR(S)
Rémen, Thomas; Coevoet, Vincent; Acouetey, Dovi-Stéphanie; Guéant, Jean-Louis; Guéant-Rodriguez, Rosa-Maria; Paris, Christophe; Zmirou-Navier, Denis
PUB. DATE
January 2010
SOURCE
BMC Public Health;2010, Vol. 10, p206
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Occupational exposures are thought to be responsible for 10-15% of new-onset asthma cases in adults, with disparities across sectors. Because most of the data are derived from registries and cross-sectional studies, little is known about incidence of occupational asthma (OA) during the first years after inception of exposure. This paper describes the design of a study that focuses on this early asthma onset period among young workers in the bakery, pastry making and hairdressing sectors in order to assess early incidence of OA in these "at risk" occupations according to exposure duration, and to identify risk factors of OA incidence. Methods/Design: The study population is composed of subjects who graduated between 2001 and 2006 in these sectors where they experience exposure to organic or inorganic allergenic or irritant compounds (with an objective of 150 subjects by year) and 250 young workers with no specific occupational exposure. A phone interview focusing on respiratory and 'Ear-Nose-Throat' (ENT) work-related symptoms screen subjects considered as "possibly OA cases". Subjects are invited to participate in a medical visit to complete clinical and lung function investigations, including fractional exhaled nitric oxide (FENO) and carbon monoxide (CO) measurements, and to collect blood samples for IgE (Immunoglobulin E) measurements (total IgE and IgE for work-related and common allergens). Markers of oxidative stress and genetic polymorphisms exploration are also assessed. A random sample of 200 "non-cases" (controls) is also visited, following a nested case-control design. Discussion: This study may allow to describ a latent period between inception of exposure and the rise of the prevalence of asthma symptoms, an information that would be useful for the prevention of OA. Such a time frame would be suited for conducting screening campaigns of this emergent asthma at a stage when occupational hygiene measures and adapted therapeutic interventions might be effective. Trial registration: Clinical trial registration number is NCT01096537.
ACCESSION #
51136637

 

Related Articles

  • Diet, occupational exposure and early asthma incidence among bakers, pastry makers and hairdressers.  // BMC Public Health;2012, Vol. 12 Issue 1, p387 

    The article presents a study that examines the combined roles of personal characteristics on the incidence of occupational asthma (OA) during the first year at work. It considers atopy as an independent risk factor of A among bakers and pastry-makers. Meanwhile, it found several variables that...

  • What is the best strategy to reduce the burden of occupational asthma and allergy in bakers? Meijster, Tim; Warren, Nick; Heederik, Dick; Tielemans, Erik // Occupational & Environmental Medicine;Mar2011, Vol. 68 Issue 3, p176 

    Rationale Insight into the effectiveness of intervention strategies will help realise a decrease in the occupational disease burden from (allergic) respiratory diseases in the bakery population. Objectives To use a simulation model to assess the impact of different intervention strategies on the...

  • Three Centuries of Research on Baker's Asthma: How Close are we to Prevention? NIEUWENHUIJSEN, MARK J.; BURDORF, ALEX // Annals of Occupational Hygiene;Feb2001, Vol. 45 Issue 2, p85 

    In this article, the author focuses on the problem of asthma in bakers. Bakers' asthma is one of the commoner occupational respiratory diseases but it is still relatively rare. Occupational asthma is defined as a reversible airway narrowing brought on by substances in the workplace. The flour...

  • The -403 G?A promoter polymorphism in the RANTES gene is associated with atopy and asthma. Fryer, A A; Spiteri, M A; Bianco, A; Hepple, M; Jones, P W; Strange, R C; Makki, R; Tavernier, G; Smilie, F I; Custovic, A; Woodcock, A A; Ollier, W E R; Hajeer, A H // Genes & Immunity;Dec2000, Vol. 1 Issue 8, p509 

    Asthma is a complex inflammatory condition often associated with bronchial hyperreactivity and atopy. Genetic and environmental factors are implicated and several candidate genes have been implicated. Of these, the chemokine RANTES is responsible for the recruitment of inflammatory cells such as...

  • Genetic polymorphism of MUC7: Allele frequencies and association with asthma. Kirkbride, Helen J; Bolscher, Jan G; Nazmi, Kamran; Vinall, Lynne E; Nash, Matthew W; Moss, Fiona M; Mitchell, David M; Swallow, Dallas M // European Journal of Human Genetics;May2001, Vol. 9 Issue 5, p347 

    MUC7 encodes a small salivary mucin, previously called MG2, a glycoprotein with a putative role in facilitating the clearance of oral bacteria. The central domain of this glycoprotein was previously shown to comprise five or six tandemly repeated units of 23 amino-acids which carry most of the...

  • Identification of novel polymorphisms in the Adam33 gene. Chae, Soo-Cheon; Yoon, Kwon-Ha; Chung, Hun-Taeg // Journal of Human Genetics;2003, Vol. 48 Issue 5, p278 

    Adam 33 is a member of a family of genes that encode membrane-anchored proteins with a disintegrin and a metalloprotease domain and that are primarily expressed in lung fibroblasts and bronchial smooth muscle. The human Adam33 gene is located on chromosome 20p13, a region that has been linked to...

  • Correction: Association between RANTES Gene Polymorphisms and Asthma: A Meta-Analysis.  // PLoS ONE;Oct2014, Vol. 9 Issue 10, p1 

    No abstract available.

  • Occupational Respiratory Symptoms in New Zealand Hairdressers. Slater, T.; Bradshaw, L.; Fishwick, D.; Cheng, S.; Kimbell-Dunn, M.; Erkinjuntti-Pekkanen, R.; Douwes, J.; Pearce, N. // Occupational Medicine;2000, Vol. 50 Issue 8, p586 

    Background A study of occupational respiratory symptoms in hairdressers was carried out in 26 salons in New Zealand. Methods A questionnaire was administered to 100 hairdressers and 106 office and shop workers, recording respiratory symptoms, demographic data, and smoking habits. Pulmonary...

  • Gene polymorphism in Netherton and common atopic disease. Walley, Andrew J.; Chavanas, Stéphane; Moffatt, Miriam F.; Esnouf, Robert M.; Ubhi, Baljinder; Lawrence, Robert; Wong, Kenny; Abecasis, Gonçalo R; Jones, E. Yvonne; Harper, John I.; Hovnanian, Alain; Cookson, William O.C.M. // Nature Genetics;Oct2001, Vol. 29 Issue 2, p175 

    Atopic dermatitis (AD) and asthma are characterized by IgE-mediated atopic (allergic) responses to common proteins (allergens), many of which are proteinases. Loci influencing atopy have been localized to a number of chromosomal regions, including the chromosome 5q31 cytokine cluster. Netherton...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics