TITLE

Inherited multicentric osteolysis: case report of three siblings treated with bisphosphonate

AUTHOR(S)
Senq-J Lee; Whitewood, Colin; Murray, Kevin J.
PUB. DATE
January 2010
SOURCE
Pediatric Rheumatology;2010, Vol. 8, p12
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Inherited Multicentric Osteolysis (IMO) is an uncommon familial condition of idiopathic pathophysiology causing bone osteolysis and dysplasia. These patients present with common rheumatologic complaints of pain, dysfunction and disability, and are often initially misdiagnosed as a chronic rheumatic disease of childhood such as juvenile idiopathic arthritis. We report a case of three siblings diagnosed with IMO. Diagnosis was made during childhood, with each sibling having different manifestations and course of disease. One had a previous history of bilateral hip dysplasia. Two had osteolysis of the foot, distal tibia and femur (lower limb bones), whilst one had osteolysis of the rib and unusual clavicular fractures. Unusually, all siblings appear to experience decreased pain sensation compared to norms. All siblings were treated with bisphosphonates and experienced a rapid improvement in pain symptoms, decreased analgesic requirements. Two had bone mineral density testing performed and both had increases postbisphosphonate. In all three, there was subjective evidence of stabilisation of bone disease. Testing for matrix metalloproteinase-2 (MMP2) gene was negative.
ACCESSION #
51112755

 

Related Articles

  • PRIMARY CEMENTLESS ACETABULAR COMPONENTS IN HIPS WITH SEVERE DEVELOPMENTAL DYSPLASIA OR TOTAL DISLOCATION. Hampton, Brett J.; Harris, William H. // Journal of Bone & Joint Surgery, American Volume;Jul2006, Vol. 88-A Issue 7, p1549 

    We previously reported the seven-year results of the use of a hemispherical, porous-coated acetabular component in twenty consecutive primary total hip arthroplasties in a highly selected group, namely, patients with severe developmental dysplasia or total dislocation of the hip. The present...

  • Screening for Developmental Dysplasia of the Hip in Newborns. EWALD, ERIC; KIESEL, ERIN // American Family Physician;1/1/2013, Vol. 87 Issue 1, p10 

    The article provides an answer to a question of how ultrasound screening for developmental dysplasia of the hip (DDH) improve long-term clinical outcomes.

  • CDH.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p394 

    An encyclopedia entry for "CDH," which refers to congenital dislocation of the hip, or congenital dysplasia of the hip, is presented.

  • A case report: zoledronic acid-induced anterior uveitis. Saadettin Kilickap; Yasemin Ozdamar; M. Altundag; Omer Dizdar // Medical Oncology;Jun2008, Vol. 25 Issue 2, p238 

    Abstract   Background Bisphosphonates prevent bone loss by binding on active sites of bone remodeling and inhibiting osteoclast-mediated bone resorption. Zoledronic acid is recommended for patients with bone metastases from breast, prostate, and lung cancers. Objective To report a case of...

  • Avascular Necrosis of the Hip: A Complication Following Treatment of Congenital Dysplasia of the Hip. Barkin, Suzanne Z.; Kondo, Kimi L.; Barkin, Roger M. // Clinical Pediatrics;May2000, Vol. 39 Issue 5, p307 

    Presents a case of a female child with avascular necrosis of the hip, a complication following treatment of congenital dysplasia of the hip. Diagnosis of avascular necrosis; Causative factor of hip dysplasia; How to correct hip biomechanics.

  • Surgical repair of chronic tears of the hip abductor mechanism. DAVIES, HYWEL; ZHAEENTAN, SOHELIA; TAVAKKOLIZADEH, ADEL; JANES, GREGORY // Hip International;Oct-Dec2009, Vol. 19 Issue 4, p372 

    Lateral sided hip pain frequently presents to the orthopaedic clinic. The most common cause of this pain is trochanteric bursitis. This usually improves with conservative treatment. In a few cases it doesn't settle and warrants further investigation and treatment. We present a series of 28...

  • Traumatic hip dislocation in a 21-month-old child. Vemulapalli, K.; Dey, C.; Peckham, T.; Paterson, J. // Archives of Orthopaedic & Trauma Surgery;Sep2005, Vol. 125 Issue 7, p490 

    Traumatic hip dislocation in the paediatric population is a relatively rare occurrence and constitutes an orthopaedic emergency. A trivial force is all that is required and non-accidental injury should not be necessarily suspected. A case report involving a hip dislocation in a 21-month-old...

  • A Rare Orthopedic Emergency: Both Fracture-Dislocation of the Shoulder and Hip in a Patient. Gürger, Murat; Gürger, Mehtap; Ateşçelik, Metin; Batur, Ömer Cihan; Çelik, Suat // Journal of Academic Emergency Medicine Case Reports / Akademik A;Oct2015, Vol. 6 Issue 4, p75 

    Introduction: Traumatic fracture-dislocations of the shoulder and hip are serious injuries caused by high-energy trauma and can lead to long-term morbidity. Case Report: In this case report, we present a case of rare orthopedic emergency due to right hip dislocation, acetabular fracture,...

  • Habitual dislocation of the hip: a rare case report. Mazhar, Farid Najd; Ghazavi, Mohammad Taghi; Gharanizadeh, Kaveh; Jafari, Davod // Medical Journal of the Islamic Republic of Iran;2014, Vol. 28, p1 

    Habitual dislocation of the hip (HDH) in children is a rare entity and can be a causative factor for popping or snapping hip which is a common problem in children with good prognosis. We report a case of HDH in a 9 year old girl who was suffering from frequent snapping hip at night, its course...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics