TITLE

Pirrolize Protein Behçet Hastalığında Yeni Bir Oksidatif Stres Belirteci Olabilir mi?

AUTHOR(S)
Kaya, Seval; Köse, Kader; Yazıcı, Cevat; Utaş, Serap; Borlu, Murat
PUB. DATE
March 2010
SOURCE
Erciyes Medical Journal / Erciyes Tip Dergisi;2010, Vol. 32 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: This study was planned to investigate whether pyrrolized-protein that occurred in oxidative conditions may be a marker for Behçet's disease suggesting that oxidative stress might play a role in its pathogenesis, and also examine the effect of N-acetylcysteine (NAC), known as a potent antioxidant, on pyrrolized-protein levels. Material and Methods: This study was performed on 40 Behçet.s patients and 20 healthy volunteers. Treatment protocol for one-month was applied to Behçet.s patients randomly subdivided into two groups NAC (2x600mg NAC/day) and placebo (2x600mg placebo/day). Pyrrolized-protein was measured in sera obtained from patient groups at the beginning and at the end of the study, and from controls once. Results: When compared to controls, pyrrolized-protein, found to be higher in both patient groups before treatment, were not changed in Placebo group; but significantly decreased and also attained to control values in NAC group after one-month treatment. Conclusion: Our results may suggest that enhanced production of ROS in Behçet.s disease may lead to protein oxidation and pyrrolized-protein determination which may be used as an oxidative-stress .marker.. In addition, the probability of NAC addition to the treatment protocols of several diseases related to oxidative stress, including Behçet.s disease, may lead to new study areas.
ACCESSION #
51010300

 

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