Progenitor cells and vascular function are impaired in patients with chronic kidney disease

Jie, Kim E.; Zaikova, Masha A.; Bergevoet, Marloes W.T.; Westerweel, Peter E.; Rastmanesh, Mehdi; Blankestijn, Peter J.; Boer, Walther H.; Braam, Branko; Verhaar, Marianne C.
June 2010
Nephrology Dialysis Transplantation;Jun2010, Vol. 25 Issue 6, p1875
Academic Journal
Background. Endothelial dysfunction contributes to accelerated atherosclerosis in chronic kidney disease (CKD). Bone marrow-derived endothelial progenitor cells (EPC) constitute an endogenous vascular repair system protecting against atherosclerosis. Smooth muscle progenitor cells (SPC) may stimulate atherosclerosis development. We hypothesized that an imbalance in EPC and SPC occurs in CKD, which may contribute to the increased cardiovascular disease (CVD) risk.


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