Astma i otyłość

Kubsik, Beata; Kowalski, Marek L.
March 2010
Alergia Astma Immunologia;2010, Vol. 15 Issue 1, p19
Academic Journal
Obesity and asthma prevalence have been increasing in parallel over the last decades. This has led to a hypothesis that these two disorders might be related. Although the exact mechanisms responsible for this relationship remain unknown, numerous published studies suggest that obesity increases the risk of the incident of asthma. Obese asthmatics may represent a distinct phenotype of asthma, characterized by: the increased asthma severity, glucocorticoid resistance and poor asthma control with the reduction in lung volumes. Systemic inflammation with the elevated levels of adipokines and cytokines and the lack of eosinophilic inflammation in airways are also typical for this phenotype. Studies have suggested that weight loss reduces symptoms, thus the treatment of obese asthmatics should include a weight control program.


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