Penetrance of NOD2/CARD15 genetic variants in the general population
- Genotype/Phenotype Analyses for 53 Crohn's Disease Associated Genetic Polymorphisms. Jung, Camille; Colombel, Jean-Frédéric; Lemann, Marc; Beaugerie, Laurent; Allez, Matthieu; Cosnes, Jacques; Vernier-Massouille, Gwenola; Gornet, Jean-Marc; Gendre, Jean-Pierre; Cezard, Jean-Pierre; Ruemmele, Frank M.; Turck, Dominique; Merlin, Françoise; Zouali, Habib; Libersa, Christian; Dieudé, Philippe; Soufir, Nadem; Thomas, Gilles; Hugot, Jean-Pierre // PLoS ONE;Dec2012, Vol. 7 Issue 12, p1
Background & Aims: Recent studies reported a role for more than 70 genes or loci in the susceptibility to Crohn's disease (CD). However, the impact of these associations in clinical practice remains to be defined. The aim of the study was to analyse the relationship between genotypes and...
- Investigation of Reported Associations Between the 20q13 and 21q22 Loci and Pediatric-Onset Crohn's Disease in Canadian Children. Amre, Devendra K.; Mack, David R.; Morgan, Kenneth; Fujiwara, Mary; Israel, David; Deslandres, Colette; Seidman, Ernest G.; Lambrette, Phlippe; Costea, Irina; Krupoves, Alfreda; Fegury, Houda; Dong, Jinsong; Grimard, Guy; Levy, Emile // American Journal of Gastroenterology;Nov2009, Vol. 104 Issue 11, p2824
OBJECTIVES:A recent pediatric-focused genome-wide association study has reported novel associations of the 20q13 and 21q22 loci with inflammatory bowel disease (IBD). We aimed to investigate these associations with Crohn's disease (CD) in Canadian children.METHODS:A combined caseâ€“control...
- How to tell its Crohn's disease. Frank, Michael S.; Ott, David J. // Patient Care;10/15/1993, Vol. 27 Issue 16, p30
Presents a guide to diagnosing Crohn's disease. Location of occurrence; Comparison with ulcerative colitis; Epidemiologic factors; Laboratory tests; Extraintestinal considerations; Radiologic and endoscopic studies; X-ray studies; Small-bowel examination; Enterolysis and peroral examination;...
- Diagnosis and treatment of Crohn's disease. Colonna, Thomas; Korelitz, Burton I. // Cortlandt Forum;8/25/95, Vol. 8 Issue 8, p169
Discusses effective methods for diagnosing and managing Crohn's disease. Definition; Causes; Difference from ulcerative colitis; Acute and chronic management; Indications for immunosuppressants; Surgical intervention; Serious complications; Long-term prognosis.
- Colonoscopy accurately predicts the anatomical severity of colonic Crohnâ€™s disease attacks: correlation with findings from colectomy specimens Nahon, Stéphane; Bouhnik, Yoram; Lavergne-Slove, Anne; Bitoun, Alain; Panis, Yves; Valleur, Patrice; Vahedi, Kouroche; Messing, Bernard; Matuchansky, Claude; Rambaud, Jean-Claude // American Journal of Gastroenterology;Dec2002, Vol. 97 Issue 12, p3102
OBJECTIVE:For the assessment of colonic Crohnâ€™s disease (CCD) attacks, no clinicobiological and/or morphological (endoscopic, radiological) criteria of severity have been validated in relation to anatomical criteria of severity (ACS) as a gold standard obtained from colectomy specimen...
- THE INCIDENCE OF CROHN'S DISEASE IN DERBY 1970-2000. Card, T.R.; Holmes, G.K.T. // Gut;Apr2003 Supplement 1, Vol. 52, pA66
Background and aims: There is good evidence to suggest that the incidence of Crohn's disease has increased in western nations including the UK since the mid 20th century. Whether this rise is ongoing however is less clear and has been the subject of debate and disagreement for some years now. We...
- First things first. Stillman, Alfred E. // Cortlandt Forum;5/25/96, Vol. 9 Issue 5, p155
Presents the case of a 22-year-old woman diagnosed to have ileocolonic Crohn's disease or regional enteritis after being operated on. Bouts of pain for one and a half weeks; Results of physical and diagnostic tests; Discovery of an inflamed mass during surgery.
- CARD15/NOD2 gene variants are associated with familially occurring and complicated forms of Crohn's disease. Heliö, T.; Halme, L.; Lappalainen, M.; Fodstad, H.; Paavola-Sakki, P.; Turunen, U.; Färkkilä, M.; Krusius, T.; Kontula, K. // Gut;Apr2003, Vol. 52 Issue 4, p558
Background: Variants of the caspase activating recruitment domain 15/nucleotide oligomerisation domain 2 (CARD15/NOD2) gene have been associated with susceptibility to Crohn's disease (CD). Aim: Our aim was to evaluate the allele frequencies of the CARD15 variants R702W, G908R, and 1007fs in...
- Crohn's disease genes identified. // Gastrointestinal Nursing;Dec2010, Vol. 8 Issue 10, p10
The article reports on the outcome of a study which shows that more genes have been associated to Crohn's disease that may lead to the development of a new treatment for such disease.