TITLE

Local Excision of Rectal Carcinoma

AUTHOR(S)
Chorost, Mitchell I.; Petrelli, Nicholas J.; Mckenna, Margo; Kraybill, William G.; Rodriguez-Bigas, Miguel A.
PUB. DATE
August 2001
SOURCE
American Surgeon;Aug2001, Vol. 67 Issue 8, p774
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The purpose of this study was to identify the recurrence rate, the salvage rate after recurrence, and the overall survival after local excision of rectal adenocarcinomas. A retrospective medical chart review was performed in 31 consecutive patients with rectal adenocarcinoma who underwent local excision at Roswell Park Cancer Institute from January 1990 through December 1999. After excision nine patients were excluded from further analysis because they were found to have advanced stage on pathologic examination (T[sub 2] primary tumors with vascular invasion or T[sub 3] tumors). Eight of the nine patients underwent abdominoperineal resection as definitive therapy. In the remaining 22 patients who underwent transanal excision as definitive surgical therapy there were 13 patients with T[sub 1] tumors and nine patients with T[sub 2] tumors. Overall seven patients (32%) developed local recurrences after local excision. This included four patients with T[sub 1] and three patients with T[sub 2] primary tumors. All recurrences occurred in the seven patients who did not receive adjuvant chemoradiation. All patients underwent salvage resection of the recurrence. Four patients who underwent salvage resection of the recurrence remain without evidence of disease at a median follow-up of 19.5 months. Local excision without adjuvant therapy has an unacceptably high rate of local recurrence. Although most patients who recur locally are salvaged by radical resection the long-term results after resection remain unknown. The use of adjuvant chemoradiation appears to reduce this high recurrence rate and may eventually become a standard adjunct to local excision of rectal cancer.
ACCESSION #
5059556

 

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