The Risk of Revision After Primary Total Hip Arthroplasty Among Statin Users

Thillemann, Theis M.; Pedersen, Alma B.; Mehnert, Frank; Johnsen, Søren P.; Søballe, Kjeld
May 2010
Journal of Bone & Joint Surgery, American Volume;May2010, Vol. 92-A Issue 5, p1063
Academic Journal
Background: Statins have been associated with beneficial effects on bone metabolism and inflammation in both experimental and clinical studies. The association between statin use and the risk of revision after primary total hip arthroplasty has not been examined. Methods: We identified 2349 patients from the Danish Hip Arthroplasty Registry who underwent revision of a primary total hip replacement in the period from 1996 to 2005 and matched them, using propensity score matching, with 2349 controls with a total hip replacement who had not had a revision. Using conditional logistic regression, we estimated the relative risk of revision due to all causes and due to specific causes according to postoperative statin use. Results: The ten-year cumulative implant revision rate in the underlying cohort of 57,581 total hip arthroplasties from the registry was 8.9% (95% confidence interval, 8.4% to 9.4%). Postoperative statin use was associated with an adjusted relative risk of revision of 0.34 (95% confidence interval, 0.28 to 0.41) compared with no use of statin. Statin use was associated with a reduced risk of revision due to deep infection, aseptic loosening, dislocation, and periprosthetic fracture. No difference in the risk of revision due to pain or implant failure was found between statin users and nonusers. Conclusions: The use of statins was associated with a substantially lower revision risk following primary total hip arthroplasty. Statins, however, should not be prescribed to healthy patients undergoing total hip arthroplastyin order to improve the longevity of the replacement until further studies have confirmed our finding and the mechanisms for this association have been clarified.


Related Articles

  • Statins are associated with improved outcomes of bloodstream infection in solid-organ transplant recipients. Hsu, J.; Andes, D. R.; Knasinski, V.; Pirsch, J.; Safdar, N. // European Journal of Clinical Microbiology & Infectious Diseases;Nov2009, Vol. 28 Issue 11, p1343 

    Among recipients of intra-abdominal solid-organ transplants, bloodstream infections (BSIs) are a major cause of mortality. We undertook a retrospective cohort study of recipients of kidney, pancreas, and/or liver transplants with BSIs at a single center over an 11-year period. Multivariate...

  • Statin Use and Risk of Sepsis After Percutaneous Nephrolithotomy. Alruwaily, Abdulrahman F.; Eisner, Brian H.; Bierlein, Maggie J.; Ghani, Khurshid R.; Wolf, J. Stuart; Hollenbeck, Brent K.; Hollingsworth, John M. // Journal of Endourology;Oct2015, Vol. 29 Issue 10, p1126 

    Purpose: To examine the association between statin medication use and sepsis risk after percutaneous nephrolithotomy (PCNL). Materials and Methods: Using medical claims data, we identified working-age adults with urinary stone disease who were treated with PCNL. Among this cohort, we determined...

  • Perioperative Testing for Joint Infection in Patients Undergoing Revision Total Hip Arthroplasty.  // Journal of Bone & Joint Surgery, American Volume;May2010, Vol. 92-A Issue 5, p1314 

    A letter to the editor and a reply are presented in response to the article "Perioperative Testing for Joint Infection in Patients Undergoing Revision Total Hip Arthroplasty," by M. F. Schinsky and colleagues.

  • Preventing Deep Wound Infection after Coronary Artery Bypass Grafting. Bryan, Charles S.; Yarbrough, William M. // Texas Heart Institute Journal;2013, Vol. 40 Issue 2, p125 

    The consequences of deep wound infections before, during, and after coronary artery bypass grafting have prompted research to clarify risk factors and explore preventive measures to keep infection rates at an irreducible minimum. An analysis of 42 studies in which investigators used multivariate...

  • Appendix Diameter: A Predictor of Wound Infection after Laparoscopic Appendectomy. HUNG-HUA LIANG; WEU WANG; MING-TE HUANG; CHIN-SHENG HUNG; KO-LI YEN; WEI-JEI LEE; CHIH-HSIUNG WU; PO-LI WEI // American Surgeon;Mar2011, Vol. 77 Issue 3, p307 

    Our aim was to investigate whether appendix diameter is an independent risk factor for wound infection in laparoscopic appendectomy (LA). Patients who underwent LA (n = 582) were grouped into those with wound infections and those without. Possible factors associated with wound infection were...

  • Does Resident Experience Affect Outcomes in Complex Abdominal Surgery? Pancreaticoduodenectomy as an Example. Relles, Daniel; Burkhart, Richard; Pucci, Michael; Sendecki, Jocelyn; Tholey, Renee; Drueding, Ross; Sauter, Patricia; Kennedy, Eugene; Winter, Jordan; Lavu, Harish; Yeo, Charles // Journal of Gastrointestinal Surgery;Feb2014, Vol. 18 Issue 2, p279 

    Objectives: Understanding the factors contributing to improved postoperative patient outcomes remains paramount. For complex abdominal operations such as pancreaticoduodenectomy (PD), the influence of provider and hospital volume on surgical outcomes has been described. The impact of resident...

  • Abdominal Wound Dehiscence in Adults: Development and Validation of a Risk Model. van Ramshorst, Gabriëlle H.; Nieuwenhuizen, Jeroen; Hop, Wim C. J.; Arends, Pauline; Boom, Johan; Jeekel, Johannes; Lange, Johan F. // World Journal of Surgery;Jan2010, Vol. 34 Issue 1, p20 

    Several studies have been performed to identify risk factors for abdominal wound dehiscence. No risk model had yet been developed for the general surgical population. The objective of the present study was to identify independent risk factors for abdominal wound dehiscence and to develop a risk...

  • High Medium-term Survival of Zweymüller SLR-Plus® Stem Used in Femoral Revision. Panagiotis Korovessis; Thomas Repantis // Clinical Orthopaedics & Related Research;Aug2009, Vol. 467 Issue 8, p2032 

    Abstract  Revision after failed THA resulting from loosening of the femoral component can be challenging even for experienced surgeons. Aseptic loosening usually is associated with some degree of bone loss. We asked whether the Zweymüller SLR-Plus®, along with allograft...

  • Dutch statin switch making sound economic sense?  // PharmacoEconomics & Outcomes News;10/2/2010, Issue 613, p7 

    The article discusses research on the switch to simvastatin from atorvastatin in the Netherlands, which references the study "The Health and Economics Impact of Switching From Atorvastatin to Generic Simvastatin in the Netherlands," by D. Liew et al.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics